| Gene Symbol |
DHCR24
|
| Entrez Gene |
1718
|
| Alt Symbol |
DCE, Nbla03646, SELADIN1, seladin-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
24-dehydrocholesterol reductase
|
| Other Description |
3 beta-hydroxysterol delta 24-reductase|3-beta-hydroxysterol delta-24-reductase|delta(24)-sterol reductase|desmosterol-to-cholesterol enzyme|diminuto/dwarf1 homolog|seladin 1|selective AD indicator 1
|
| Swissprots |
Q9HBA8 D3DQ51 Q15392 B7Z817
|
| Accessions |
AAL15644 EAX06663 EAX06664 Q15392 AB073391 BAE45721 AF261758 AAG17288 AI952034 AK298414 BAH12782 AK302774 BAH13803 AK304302 BAH14155 AK304421 BAH14179 AK304437 BAH14186 AK316419 BAH14790 AK316427 BAH14798 BC004375 AAH04375 BC011669 AAH11669 BP200916 BQ439951 D13643 BAA02806 DQ893405 ABM84331 DQ896723 ABM87722 NM_014762 NP_055577
|
| Function |
Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011, ECO:0000269|PubMed:22010141}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
|
| Tissue Specificity |
Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex. {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011}.
|
| Top Pathways |
Steroid biosynthesis
|
![Western Blot: Seladin 1 Overexpression Lysate (Adult Normal) [NBL1-09857] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Seladin 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5848_Seladin%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09857-img0002.jpg)