DHCR24

Gene Symbol	DHCR24
Entrez Gene	1718
Alt Symbol	DCE, Nbla03646, SELADIN1, seladin-1
Species	Human
Gene Type	protein-coding
Description	24-dehydrocholesterol reductase
Other Description	3 beta-hydroxysterol delta 24-reductase|3-beta-hydroxysterol delta-24-reductase|delta(24)-sterol reductase|desmosterol-to-cholesterol enzyme|diminuto/dwarf1 homolog|seladin 1|selective AD indicator 1
Swissprots	Q9HBA8 D3DQ51 Q15392 B7Z817
Accessions	AAL15644 EAX06663 EAX06664 Q15392 AB073391 BAE45721 AF261758 AAG17288 AI952034 AK298414 BAH12782 AK302774 BAH13803 AK304302 BAH14155 AK304421 BAH14179 AK304437 BAH14186 AK316419 BAH14790 AK316427 BAH14798 BC004375 AAH04375 BC011669 AAH11669 BP200916 BQ439951 D13643 BAA02806 DQ893405 ABM84331 DQ896723 ABM87722 NM_014762 NP_055577
Function	Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011, ECO:0000269|PubMed:22010141}.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Tissue Specificity	Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex. {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011}.
Top Pathways	Steroid biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Seladin 1 peptide - ab41486 from Abcam Category Peptide

DHCR24 / Seladin-1 Antibody Blocking Peptide - LS-E7140 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DHCR24 / Seladin-1 Antibody Blocking Peptide - LS-E7141 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DHCR24 / Seladin-1 Antibody Blocking Peptide - LS-E17092 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Seladin 1 Protein - H00001718-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

DHCR24-Antibody-Center-Blocking-Peptide - BP2840c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DHCR24-Antibody-N-term-Blocking-Peptide - BP2840a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DHCR24 Blocking Peptide - 33R-1138 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DHCR24 Blocking Peptide - 33R-2970 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Seladin-1 / DHCR24 - H00001718-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

DHCR24 fusion protein - Ag0756 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

DHCR24 fusion protein - ag17780 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human DHCR24, GST-tagged - DHCR24-11962H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Delta(24)-sterol reductase(DHCR24) - CSB-YP618005HU CSB-EP618005HU CSB-BP618005HU CSB-MP618005HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Seladin-1 / DHCR24 - TP303507 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Seladin 1 Protein - NBP2-38980PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

DHCR24 Peptide, Human - M34GP04261H from Creative Peptides Category Peptide Source Synthetic. Species Human

Delta (24)-sterol reductase (DHCR24), Recombinant Protein - MBS1381223 from MyBioSource Category Protein Prices $1,245.00, $1,245.00, $1,465.00, $1,465.00, $2,030.00, $2,030.00, $2,495.00, $2,495.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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