DHCR24

Gene Symbol DHCR24
Entrez Gene 1718
Alt Symbol DCE, Nbla03646, SELADIN1, seladin-1
Species Human
Gene Type protein-coding
Description 24-dehydrocholesterol reductase
Other Description 3 beta-hydroxysterol delta 24-reductase|3-beta-hydroxysterol delta-24-reductase|delta(24)-sterol reductase|desmosterol-to-cholesterol enzyme|diminuto/dwarf1 homolog|seladin 1|selective AD indicator 1
Swissprots Q9HBA8 D3DQ51 Q15392 B7Z817
Accessions AAL15644 EAX06663 EAX06664 Q15392 AB073391 BAE45721 AF261758 AAG17288 AI952034 AK298414 BAH12782 AK302774 BAH13803 AK304302 BAH14155 AK304421 BAH14179 AK304437 BAH14186 AK316419 BAH14790 AK316427 BAH14798 BC004375 AAH04375 BC011669 AAH11669 BP200916 BQ439951 D13643 BAA02806 DQ893405 ABM84331 DQ896723 ABM87722 NM_014762 NP_055577
Function Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011, ECO:0000269|PubMed:22010141}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Tissue Specificity Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex. {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011}.
Top Pathways Steroid biosynthesis

DHCR24 CRISPR/Cas9 KO Plasmid (h) - sc-405507 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHCR24 HDR Plasmid (h) - sc-405507-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHCR24 Double Nickase Plasmid (h) - sc-405507-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHCR24 Double Nickase Plasmid (h2) - sc-405507-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHCR24 CRISPR Activation Plasmid (h) - sc-405507-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHCR24 CRISPR Activation Plasmid (h2) - sc-405507-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHCR24 Lentiviral Activation Particles (h) - sc-405507-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHCR24 Lentiviral Activation Particles (h2) - sc-405507-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHCR24 siRNA (h) - sc-60531 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DHCR24 shRNA Plasmid (h) - sc-60531-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DHCR24 shRNA (h) Lentiviral Particles - sc-60531-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU008051 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7189 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7189 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11617 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11617

DHCR24 siRNA (Human) - CRH1192 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DHCR24 - MBS8235363 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DHCR24 (NM_014762.3) - SHH277565 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human DHCR24(NM_014762.3) - SHH003341 from Creative biogene

Category siRNA
Species Reactivities Human

DHCR24 shRNA Plasmid (Human) - CHH1192 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DHCR24 miRNA 3'UTR clone - MiUTR4H-TG02705 from Creative biogene

Species Reactivities Human
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