DHCR24

Gene Symbol DHCR24
Entrez Gene 1718
Alt Symbol DCE, Nbla03646, SELADIN1, seladin-1
Species Human
Gene Type protein-coding
Description 24-dehydrocholesterol reductase
Other Description 3 beta-hydroxysterol delta 24-reductase|3-beta-hydroxysterol delta-24-reductase|delta(24)-sterol reductase|desmosterol-to-cholesterol enzyme|diminuto/dwarf1 homolog|seladin 1|selective AD indicator 1
Swissprots Q9HBA8 D3DQ51 Q15392 B7Z817
Accessions AAL15644 EAX06663 EAX06664 Q15392 AB073391 BAE45721 AF261758 AAG17288 AI952034 AK298414 BAH12782 AK302774 BAH13803 AK304302 BAH14155 AK304421 BAH14179 AK304437 BAH14186 AK316419 BAH14790 AK316427 BAH14798 BC004375 AAH04375 BC011669 AAH11669 BP200916 BQ439951 D13643 BAA02806 DQ893405 ABM84331 DQ896723 ABM87722 NM_014762 NP_055577
Function Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011, ECO:0000269|PubMed:22010141}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Tissue Specificity Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex. {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011}.
Top Pathways Steroid biosynthesis

DHCR24/Seladin-1 (C59D8) Rabbit mAb - 2033 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C59D8
Western blot analysis of extracts from various cell types using DHCR24/Seladin-1 (C59D8) Rabbit mAb.

DHCR24 (A-4) - sc-398938 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DHCR24 (A-4): sc-398938. Western blot analysis of DHCR24 expression in Hep G2 (A) and NIH/3T3 (B) whole cell lysates.

DHCR24 (N-17) - sc-48477 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DHCR24 (N-17): sc-48477. Western blot analysis of DHCR24 expression in non-transfected (A) and human DHCR24 transfected (B) whole cell lysates.

DHCR24 (N-16) - sc-48476 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DHCR24 (N-16): sc-48476. Western blot analysis of DHCR24 expression in non-transfected (A) and human DHCR24 transfected (B) whole cell lysates.

DHCR24 (H-300) - sc-134568 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

DHCR24 (N-15) - sc-48475 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DHCR24 (N-15): sc-48475. Western blot analysis of DHCR24 expression in PC-12 (A) and A-375 (B) whole cell lysates.

DHCR24 (D-10) - sc-390037 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DHCR24 (D-10): sc-390037. Western blot analysis of DHCR24 expression in Hep G2 (A), A-375 (B) and 293T (C) whole cell lysates.

Anti-Seladin 1 antibody - ab137845 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Seladin 1 antibody (ab137845) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-Seladin 1 antibody - ab40490 from Abcam

Prices $380.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Seladin 1 antibody (ab40490) at 1 µg/mlLane 1 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 2 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431)Lane 3 : Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-Seladin 1 antibody - ab171878 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Seladin 1 antibody (ab171878) at 1 µg/mlLane 1 : Seladin 1 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgGb at 1/2500 dilution

Anti-Seladin 1 antibody - ab98345 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Seladin 1 antibody (ab98345) at 1 µg/ml + THP1 cell lysate at 10 µg

Anti-Seladin 1 antibody [EPR10743] - ab181062 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10743
All lanes : Anti-Seladin 1 antibody [EPR10743] (ab181062) at 1/1000 dilutionLane 1 : A375 cell lysateLane 2 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-DHCR24 / Seladin-1 Antibody - LS-C307233 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-DHCR24 / Seladin-1 Antibody - LS-C310121 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DHCR24 / Seladin-1 Antibody (aa38-87) - LS-C80987 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-DHCR24 / Seladin-1 Antibody - LS-C341786 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DHCR24 / Seladin-1 Antibody (aa57-87) - LS-C97330 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-DHCR24 Antibody in mouse liver tissue lysates (35 ug/lane). DHCR24 (arrow) was detected using the purified antibody.

Anti-DHCR24 / Seladin-1 Antibody (aa218-246) - LS-C97331 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-DHCR24 Antibody in HepG2 cell line lysates (35 ug/lane). DHCR24 (arrow) was detected using the purified antibody.

Anti-DHCR24 / Seladin-1 Antibody - LS-C334040 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using DHCR24 antibody.

Anti-DHCR24 / Seladin-1 Antibody (aa431-480) - LS-C107889 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DHCR24 / Seladin-1 antibody LS-C107889 Western blot of THP-1 cell lysate.

Seladin 1 Antibody - NBP1-32247 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Seladin 1 Antibody [NBP1-32247] - Sample (30 ug of whole cell lysate) A: A431 7. 5% SDS PAGE Seladin 1 antibody, antibody diluted at 1:1000.

Seladin 1 Antibody - NBP2-38980 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Seladin 1 Antibody [NBP2-38980] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative Control. Lane 3: Overexpression lysate

Seladin 1 Antibody - NBP1-59369 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Seladin 1 Antibody [NBP1-59369] - Human Fetal Heart, Antibody Dilution: 1.0 ug/ml.

Seladin 1 Antibody - H00001718-B01P from Novus Biologicals

Prices $349.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: Seladin 1 Antibody [H00001718-B01P] - analysis of DHCR24 expression in transfected 293T cell line by DHCR24 MaxPab polyclonal antibody. Lane 1: DHCR24 transfected lysate (56.76 KDa). Lane 2: Non-transfected lysate.

Seladin 1 Antibody - H00001718-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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