Gene Symbol | PTGFR |
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Entrez Gene | 5737 |
Alt Symbol | FP |
Species | Human |
Gene Type | protein-coding |
Description | prostaglandin F receptor (FP) |
Other Description | PGF receptor|PGF2 alpha receptor|PGF2-alpha receptor|prostaglandin F2 alpha receptor|prostaglandin F2-alpha receptor|prostaglandin receptor (2-alpha)|prostanoid FP receptor |
Swissprots | P43088 Q2KHP3 Q9P1X4 Q6RYQ6 A8K9Y0 |
Accessions | BAA94756 BAE03222 CAI53641 CAI53647 EAX06350 EAX06351 P43088 AF004021 AAB63152 AK292845 BAF85534 AK312816 AY337000 AAQ76788 AY485530 AAR84381 BC112965 AAI12966 BG771316 BQ897935 CA429969 CD013876 DQ890957 ABM81883 DQ894120 ABM85046 H02113 L24470 AAA17684 XM_006710781 XP_006710844 XR_426624 XR_946715 NM_000959 NP_000950 NM_001039585 NP_001034674 |
Function | Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost. {ECO:0000250, ECO:0000269|PubMed:18587449}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Eye. {ECO:0000269|PubMed:18587449}. |
Top Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |
PGF2αR (H-55) - sc-67029 from Santa Cruz Biotechnology
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PGF2αR (K-14) - sc-33364 from Santa Cruz Biotechnology
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PGF2αR (T-15) - sc-46449 from Santa Cruz Biotechnology
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PGF2αR (N-18) - sc-33363 from Santa Cruz Biotechnology
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Anti-Prostaglandin F2 alpha Receptor antibody - ab203342 from Abcam
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Anti-Prostaglandin F2 alpha Receptor antibody [EPR5844] - ab126709 from Abcam
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Anti-FP / PTGFR Antibody (C-Terminus, clone EPR5844) - LS-C152330 from LifeSpan Bioscience
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Anti-FP / PTGFR Antibody - LS-C146662 from LifeSpan Bioscience
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Anti-FP / PTGFR Antibody (Cytoplasmic Domain) IHC-plus⢠- LS-A1048 from LifeSpan Bioscience
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Anti-FP / PTGFR Antibody (Extracellular Domain) IHC-plus⢠- LS-A1049 from LifeSpan Bioscience
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Anti-FP / PTGFR Antibody (Cytoplasmic Domain) IHC-plus⢠- LS-A6625 from LifeSpan Bioscience
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Anti-FP / PTGFR Antibody (Extracellular Domain) IHC-plus⢠- LS-A6624 from LifeSpan Bioscience
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Anti-FP / PTGFR Antibody (aa199-248) - LS-C151890 from LifeSpan Bioscience
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PTGFR Antibody - NLS1049 from Novus Biologicals
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PTGFR Antibody - NLS6624 from Novus Biologicals
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PTGFR Antibody - NLS1048 from Novus Biologicals
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PTGFR Polyclonal antibody - bs-10433R from Bioss
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PTGFR Polyclonal antibody, ALEXA FLUOR® 350 Conjugated - bs-10433R-A350 from Bioss
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PTGFR Polyclonal antibody, ALEXA FLUOR® 488 Conjugated - bs-10433R-A488 from Bioss
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PTGFR Polyclonal antibody, ALEXA FLUOR® 555 Conjugated - bs-10433R-A555 from Bioss
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PTGFR Polyclonal antibody, ALEXA FLUOR® 647 Conjugated - bs-10433R-A647 from Bioss
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PTGFR Polyclonal antibody, Cy3 Conjugated - bs-10433R-Cy3 from Bioss
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PTGFR Polyclonal antibody, Cy5 Conjugated - bs-10433R-Cy5 from Bioss
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PTGFR Polyclonal antibody, Cy5.5 Conjugated - bs-10433R-Cy5.5 from Bioss
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PTGFR Polyclonal antibody, Cy7 Conjugated - bs-10433R-Cy7 from Bioss
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