| Gene Symbol |
PTGFR
|
| Entrez Gene |
5737
|
| Alt Symbol |
FP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prostaglandin F receptor (FP)
|
| Other Description |
PGF receptor|PGF2 alpha receptor|PGF2-alpha receptor|prostaglandin F2 alpha receptor|prostaglandin F2-alpha receptor|prostaglandin receptor (2-alpha)|prostanoid FP receptor
|
| Swissprots |
P43088 Q2KHP3 Q9P1X4 Q6RYQ6 A8K9Y0
|
| Accessions |
BAA94756 BAE03222 CAI53641 CAI53647 EAX06350 EAX06351 P43088 AF004021 AAB63152 AK292845 BAF85534 AK312816 AY337000 AAQ76788 AY485530 AAR84381 BC112965 AAI12966 BG771316 BQ897935 CA429969 CD013876 DQ890957 ABM81883 DQ894120 ABM85046 H02113 L24470 AAA17684 XM_006710781 XP_006710844 XR_426624 XR_946715 NM_000959 NP_000950 NM_001039585 NP_001034674
|
| Function |
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost. {ECO:0000250, ECO:0000269|PubMed:18587449}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Eye. {ECO:0000269|PubMed:18587449}.
|
| Top Pathways |
Calcium signaling pathway, Neuroactive ligand-receptor interaction
|