| Gene Symbol |
AXIN2
|
| Entrez Gene |
8313
|
| Alt Symbol |
AXIL, ODCRCS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
axin 2
|
| Other Description |
axin-2|axin-like protein|axis inhibition protein 2|conductin
|
| Swissprots |
Q9UH84 Q9H3M6 Q3MJ88 Q9Y2T1
|
| Accessions |
EAW89003 EAW89004 EAW89005 EAW89006 Q9Y2T1 AB052751 BAB19762 AF078165 AAD20976 AF205888 AAF22799 AK025718 AK315303 BC006295 AAH06295 BC101533 AAI01534 BC143244 AAI43245 BE670767 CB306601 CR933657 CAI45956 CX756263 CX759580 DA785881 DA839648 XM_011525319 XP_011523621 XM_011525320 XP_011523622 XM_011525321 XP_011523623 XM_011525322 XP_011523624 NM_004655 NP_004646
|
| Function |
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Expressed in brain and lymphoblast.
|
| Top Pathways |
Wnt signaling pathway, Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Hippo signaling pathway
|