Gene Symbol | AXIN2 |
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Entrez Gene | 8313 |
Alt Symbol | AXIL, ODCRCS |
Species | Human |
Gene Type | protein-coding |
Description | axin 2 |
Other Description | axin-2|axin-like protein|axis inhibition protein 2|conductin |
Swissprots | Q9UH84 Q9H3M6 Q3MJ88 Q9Y2T1 |
Accessions | EAW89003 EAW89004 EAW89005 EAW89006 Q9Y2T1 AB052751 BAB19762 AF078165 AAD20976 AF205888 AAF22799 AK025718 AK315303 BC006295 AAH06295 BC101533 AAI01534 BC143244 AAI43245 BE670767 CB306601 CR933657 CAI45956 CX756263 CX759580 DA785881 DA839648 XM_011525319 XP_011523621 XM_011525320 XP_011523622 XM_011525321 XP_011523623 XM_011525322 XP_011523624 NM_004655 NP_004646 |
Function | Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Expressed in brain and lymphoblast. |
Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Hippo signaling pathway |
Conductin CRISPR/Cas9 KO Plasmid (h) - sc-401386 from Santa Cruz Biotechnology
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Conductin HDR Plasmid (h) - sc-401386-HDR from Santa Cruz Biotechnology
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Conductin Double Nickase Plasmid (h) - sc-401386-NIC from Santa Cruz Biotechnology
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Conductin Double Nickase Plasmid (h2) - sc-401386-NIC-2 from Santa Cruz Biotechnology
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Conductin CRISPR Activation Plasmid (h) - sc-401386-ACT from Santa Cruz Biotechnology
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Conductin CRISPR Activation Plasmid (h2) - sc-401386-ACT-2 from Santa Cruz Biotechnology
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Conductin Lentiviral Activation Particles (h) - sc-401386-LAC from Santa Cruz Biotechnology
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Conductin Lentiviral Activation Particles (h2) - sc-401386-LAC-2 from Santa Cruz Biotechnology
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Conductin siRNA (h) - sc-35087 from Santa Cruz Biotechnology
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Conductin shRNA Plasmid (h) - sc-35087-SH from Santa Cruz Biotechnology
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Conductin shRNA (h) Lentiviral Particles - sc-35087-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU001481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3786 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3786 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09481 from Sigma-Aldrich
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AXIN2 siRNA (Human) - CRH5437 from Cohesion Biosciences
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AXIN2 - MBS8211788 from MyBioSource
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shRNA set against Human AXIN2 (NM_004655.3) - SHH243950 from Creative biogene
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Human AXIN2 siRNA - orb265939 from Biorbyt
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AXIN2 shRNA Plasmid (Human) - CHH5437 from Cohesion Biosciences
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AXIN2 miRNA 3'UTR clone - MiUTR3H-06444 from Creative biogene
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