Gene Symbol | CHTF18 |
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Entrez Gene | 63922 |
Alt Symbol | C16orf41, C321D2.2, C321D2.3, C321D2.4, CHL12, Ctf18, RUVBL |
Species | Human |
Gene Type | protein-coding |
Description | CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) |
Other Description | C321D2.3 (novel protein)|C321D2.4 (novel protein)|chromosome transmission fidelity protein 18 homolog|hCTF18|homolog of yeast CHL12|some homology with holliday junction DNA helicase RUVB like |
Swissprots | B7ZBA2 Q9BRG5 Q9BR83 Q9H7K3 Q7Z6Y6 Q7Z6Y4 Q8WVB6 D3DU68 |
Accessions | AAK61256 EAW85704 EAW85705 EAW85706 EAW85707 EAW85708 EAW85709 EAW85710 EAW85711 Q8WVB6 AI650845 AK024476 BAB15766 AK128869 AK293846 BAG57244 AK309804 BC006278 AAH06278 BC006437 AAH06437 BC018184 AAH18184 DC410609 XM_005255470 XP_005255527 XM_005255471 XP_005255528 XM_005255472 XP_005255529 XM_011522572 XP_011520874 XM_011522573 XP_011520875 NM_022092 NP_071375 |
Function | Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18- RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH. {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12766176}. Note=Associates with chromatin during S phase. |
Rabbit anti-CTF18 Antibody, Affinity Purified - PLA0220 from Sigma-Aldrich
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Chromosome transmission fidelity protein 18 homolog (CHTF18), Human, ELISA Kit - E01C1719 from ARP American Research Products
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Chromosome transmission fidelity protein 18 homolog (CHTF18), ELISA Kit - MBS7223826 from MyBioSource
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Chromosome transmission fidelity protein 18 homolog (CHTF18), ELISA Kit - MBS7217683 from MyBioSource
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Chromosome transmission fidelity protein 18 homolog (CHTF18), ELISA Kit - MBS7249446 from MyBioSource
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Chromosome transmission fidelity protein 18 homolog (CHTF18), ELISA Kit - MBS7242598 from MyBioSource
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Chromosome transmission fidelity protein 18 homolog (CHTF18), ELISA Kit - MBS7203217 from MyBioSource
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Chromosome transmission fidelity protein 18 homolog (CHTF18), ELISA Kit - MBS7235482 from MyBioSource
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Chromosome transmission fidelity protein 18 homolog (CHTF18), ELISA Kit - MBS7214260 from MyBioSource
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Chromosome transmission fidelity protein 18 homolog (CHTF18), ELISA Kit - MBS7214277 from MyBioSource
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Chromosome transmission fidelity protein 18 homolog (CHTF18), ELISA Kit - MBS7209947 from MyBioSource
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Chromosome transmission fidelity protein 18 homolog (CHTF18), ELISA Kit - MBS7242719 from MyBioSource
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Chromosome transmission fidelity protein 18 homolog (CHTF18), ELISA Kit - MBS7206636 from MyBioSource
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Chromosome transmission fidelity protein 18 homolog (CHTF18), ELISA Kit - MBS7207417 from MyBioSource
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Human CHTF18 ELISA Kit - E009404 from Biobool
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