CHTF18
| Gene Symbol | CHTF18 |
|---|---|
| Entrez Gene | 63922 |
| Alt Symbol | C16orf41, C321D2.2, C321D2.3, C321D2.4, CHL12, Ctf18, RUVBL |
| Species | Human |
| Gene Type | protein-coding |
| Description | CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) |
| Other Description | C321D2.3 (novel protein)|C321D2.4 (novel protein)|chromosome transmission fidelity protein 18 homolog|hCTF18|homolog of yeast CHL12|some homology with holliday junction DNA helicase RUVB like |
| Swissprots | B7ZBA2 Q9BRG5 Q9BR83 Q9H7K3 Q7Z6Y6 Q7Z6Y4 Q8WVB6 D3DU68 |
| Accessions | AAK61256 EAW85704 EAW85705 EAW85706 EAW85707 EAW85708 EAW85709 EAW85710 EAW85711 Q8WVB6 AI650845 AK024476 BAB15766 AK128869 AK293846 BAG57244 AK309804 BC006278 AAH06278 BC006437 AAH06437 BC018184 AAH18184 DC410609 XM_005255470 XP_005255527 XM_005255471 XP_005255528 XM_005255472 XP_005255529 XM_011522572 XP_011520874 XM_011522573 XP_011520875 NM_022092 NP_071375 |
| Function | Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18- RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH. {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:12766176}. Note=Associates with chromatin during S phase. |
CTF18 CRISPR/Cas9 KO Plasmid (h) - sc-407690 from Santa Cruz Biotechnology
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CTF18 HDR Plasmid (h) - sc-407690-HDR from Santa Cruz Biotechnology
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CTF18 Double Nickase Plasmid (h) - sc-407690-NIC from Santa Cruz Biotechnology
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CTF18 Double Nickase Plasmid (h2) - sc-407690-NIC-2 from Santa Cruz Biotechnology
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CTF18 CRISPR Activation Plasmid (h) - sc-407690-ACT from Santa Cruz Biotechnology
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CTF18 CRISPR Activation Plasmid (h2) - sc-407690-ACT-2 from Santa Cruz Biotechnology
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CTF18 Lentiviral Activation Particles (h) - sc-407690-LAC from Santa Cruz Biotechnology
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CTF18 Lentiviral Activation Particles (h2) - sc-407690-LAC-2 from Santa Cruz Biotechnology
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CTF18 siRNA (h) - sc-93208 from Santa Cruz Biotechnology
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CTF18 shRNA Plasmid (h) - sc-93208-SH from Santa Cruz Biotechnology
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CTF18 shRNA (h) Lentiviral Particles - sc-93208-V from Santa Cruz Biotechnology
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CHTF18 RNAi - H00063922-R02 from Novus Biologicals
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MISSION® esiRNA - EHU157791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6120 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6120 from Sigma-Aldrich
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CHTF18 siRNA (Human) - CRJ1862 from Cohesion Biosciences
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CHTF18 - MBS8200469 from MyBioSource
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shRNA set against Human CHTF18 (NM_022092.2) - SHH263901 from Creative biogene
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shRNA set against Human CHTF18(NM_022092.2) - SHG178453 from Creative biogene
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Human CHTF18 siRNA - orb272363 from Biorbyt
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CHTF18 shRNA Plasmid (Human) - CHJ1862 from Cohesion Biosciences
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CHTF18 miRNA 3'UTR clone - MiUTR1H-02155 from Creative biogene
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