AGER

Gene Symbol	AGER
Entrez Gene	177
Alt Symbol	RAGE
Species	Human
Gene Type	protein-coding
Description	advanced glycosylation end product-specific receptor
Other Description	RAGE isoform NtRAGE-delta|RAGE isoform sRAGE-delta|receptor for advanced glycation end-products variant 20
Swissprots	B0V176 Q9H2X7 Q9Y3R3 Q3L1R5 Q15279 A2BFI7 V5R6A3 Q3L1R4 A7Y2U9 Q3L1R8 Q15109 Q3L1R6 Q3L1R7 A6NKF0 Q86SN1 Q3L1S0
Accessions	AAB47491 AAD15888 AAD15889 AAG35728 BAA05958 CAA10169 CAB43094 CAK32486 EAX03610 EAX03611 Q15109 AB036432 BAA89369 AB061668 BAC65465 AB061669 BAC65466 AF536236 AAQ10685 AF536237 AAQ10686 AF537303 AAQ10782 AJ133822 CAB43108 AK298100 BAG60385 AK313178 BAG35995 AY755619 AAX07272 AY755620 AAX07273 AY755621 AAX07274 AY755622 AAX07275 AY755623 AAX07276 AY755624 AAX07277 AY755625 AAX07278 AY755626 AAX07279 AY755627 AAX07280 AY755628 AAX07281 BC020669 AAH20669 BM971899 DQ104251 AAZ32412 DQ104252 AAZ32413 DQ104253 AAZ32414 DQ104254 AAZ32415 DQ893575 ABM84501 DQ896821 ABM87820 EU117141 ABV03807 EU428811 ACE78167 EU428812 ACE78168 EU428813 ACE78169 EU428814 EU428815 ACE78170 EU428816 EU826616 ACF47652 EU826617 ACF47653 EU826618 ACF47654 EU826619 ACF47655 EU826620 ACF47656 FJ545655 ACL80027 GU139370 GU139371 ADQ42256 GU139372 GU139373 ADQ42257 GU139374 ADQ42258 GU139375 ADQ42259 GU139376 ADQ42260 GU139377 ADQ42261 GU139378 ADQ42262 GU139379 GU139380 GU139381 GU139382 GU139383 GU139384 HQ148133 ADV92535 HQ148134 ADV92536 HQ148135 ADV92537 KC692917 AHB30241 M91211 AAA03574 NM_001136 NP_001127 NM_001206929 NP_001193858 NM_001206932 NP_001193861 NM_001206934 NP_001193863 NM_001206936 NP_001193865 NM_001206940 NP_001193869 NM_001206954 NP_001193883 NM_001206966 NP_001193895 NM_172197 NP_751947 NR_038190
Function	Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular sp
Subcellular Location	Isoform 10: Cell membrane {ECO:0000269|PubMed:24260107}; Single-pass type I membrane protein {ECO:0000269|PubMed:24260107}.
Tissue Specificity	Endothelial cells.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-AGER-cDNA-Clone - DC04946 from Abgent, a WuXi AppTec company Prices $545.40 Sizes 10 µg Species Human Accession BC020669

AGER - MBS1274209 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC020669

Human AGER ORF Clone(NM_001136.4) - CDCL153328 from Creative Biomart Species Human Accession NM_001136.4

Human AGER transcript variant 1 Gene cDNA clone plasmid - HG11629-M from Sino Biological Species Human

Human RAGE/AGER transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11629-NY from Sino Biological Species Human

Human RAGE/AGER transcript variant 1 Gene ORF cDNA clone expression plasmid - HG11629-UT from Sino Biological Species Human

Human RAGE/AGER transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG11629-NH from Sino Biological Species Human

Human RAGE/AGER transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG11629-CH from Sino Biological Species Human

Human RAGE/AGER transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11629-CY from Sino Biological Species Human

Human RAGE/AGER transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11629-ACR from Sino Biological Species Human

Human AGER transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11629-M-N from Sino Biological Species Human Accession NM_001136.3

Human RAGE/AGER transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11629-NF from Sino Biological Species Human

Human RAGE/AGER transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11629-ACG from Sino Biological Species Human

Human RAGE/AGER transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11629-CF from Sino Biological Species Human

Human RAGE/AGER transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11629-NM from Sino Biological Species Human

Human RAGE/AGER transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11629-CM from Sino Biological Species Human

AGER - CL01094H01 from Elabscience Species Human Accession NM_001136.4

AGER - CL01094H02 from Elabscience Species Human Accession NM_001206929.1

AGER - CL01094H03 from Elabscience Species Human Accession NM_001206932.1

AGER - CL01094H04 from Elabscience Species Human Accession NM_001206934.1

Human AGER ORF Clone (BC020669) - CDCS408151 from Creative biogene Species Human Accession Q15109

Human AGER ORF Clone (BC053536) - CDCS417989 from Creative biogene Species Human Accession Q15109

Human AGER ORF clone (NM_001136.3) - CDCB160333 from Creative biogene Species Human

Mouse RAGE (NP_031451) VersaClone cDNA - RDC1847 from R&D Systems Prices $199.00 Sizes 10 µg Species Mouse

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