AGER

Gene Symbol AGER
Entrez Gene 177
Alt Symbol RAGE
Species Human
Gene Type protein-coding
Description advanced glycosylation end product-specific receptor
Other Description RAGE isoform NtRAGE-delta|RAGE isoform sRAGE-delta|receptor for advanced glycation end-products variant 20
Swissprots B0V176 Q9H2X7 Q9Y3R3 Q3L1R5 Q15279 A2BFI7 V5R6A3 Q3L1R4 A7Y2U9 Q3L1R8 Q15109 Q3L1R6 Q3L1R7 A6NKF0 Q86SN1 Q3L1S0
Accessions AAB47491 AAD15888 AAD15889 AAG35728 BAA05958 CAA10169 CAB43094 CAK32486 EAX03610 EAX03611 Q15109 AB036432 BAA89369 AB061668 BAC65465 AB061669 BAC65466 AF536236 AAQ10685 AF536237 AAQ10686 AF537303 AAQ10782 AJ133822 CAB43108 AK298100 BAG60385 AK313178 BAG35995 AY755619 AAX07272 AY755620 AAX07273 AY755621 AAX07274 AY755622 AAX07275 AY755623 AAX07276 AY755624 AAX07277 AY755625 AAX07278 AY755626 AAX07279 AY755627 AAX07280 AY755628 AAX07281 BC020669 AAH20669 BM971899 DQ104251 AAZ32412 DQ104252 AAZ32413 DQ104253 AAZ32414 DQ104254 AAZ32415 DQ893575 ABM84501 DQ896821 ABM87820 EU117141 ABV03807 EU428811 ACE78167 EU428812 ACE78168 EU428813 ACE78169 EU428814 EU428815 ACE78170 EU428816 EU826616 ACF47652 EU826617 ACF47653 EU826618 ACF47654 EU826619 ACF47655 EU826620 ACF47656 FJ545655 ACL80027 GU139370 GU139371 ADQ42256 GU139372 GU139373 ADQ42257 GU139374 ADQ42258 GU139375 ADQ42259 GU139376 ADQ42260 GU139377 ADQ42261 GU139378 ADQ42262 GU139379 GU139380 GU139381 GU139382 GU139383 GU139384 HQ148133 ADV92535 HQ148134 ADV92536 HQ148135 ADV92537 KC692917 AHB30241 M91211 AAA03574 NM_001136 NP_001127 NM_001206929 NP_001193858 NM_001206932 NP_001193861 NM_001206934 NP_001193863 NM_001206936 NP_001193865 NM_001206940 NP_001193869 NM_001206954 NP_001193883 NM_001206966 NP_001193895 NM_172197 NP_751947 NR_038190
Function Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular sp
Subcellular Location Isoform 10: Cell membrane {ECO:0000269|PubMed:24260107}; Single-pass type I membrane protein {ECO:0000269|PubMed:24260107}.
Tissue Specificity Endothelial cells.

RAGE 1 Antibody - 4800 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extract from human lung tissue using RAGE 1 Antibody.

RAGE Antibody - 4679 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from human, mouse and rat lung tissue using RAGE Antibody.

RAGE 1 (D1A12) Rabbit mAb - 6996 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1A12
Western blot analysis of extracts from human lung tissue using RAGE 1 (D1A12) Rabbit mAb.

RAGE (A-9) - sc-365154 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RAGE (A-9): sc-365154. Western blot analysis of RAGE expression in A549 whole cell lysate.

RAGE (D-5) - sc-74535 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RAGE (D-5): sc-74535. Western blot analysis of human recombinant RAGE protein.

RAGE (E-1) - sc-74473 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RAGE (E-1): sc-74473. Western blot analysis of human recombinant RAGE.

RAGE (RD9C 2) - sc-33662 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RAGE (RD9C 2): sc-33662. Western blot analysis of RAGE expression in MCF7 (A), HUV-EC-C (B) and ECV304 (C) whole cell lysates.

RAGE (9A11) - sc-80653 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RAGE (9A11): sc-80653. Western blot analysis of human recombinant RAGE/Fc Chimera monomer under reducing conditions.

RAGE (N-16) - sc-8230 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RAGE (N-16): sc-8230. Immunofluorescence staining of methanol-fixed A549 cells showing membrane staining.

RAGE (A11) - sc-80652 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RAGE (A11): sc-80652. Western blot analysis of human recombinant RAGE/Fc Chimera monomer under reducing conditions.

RAGE (C-20) - sc-8229 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RAGE (C-20): sc-8229. Western blot analysis of RAGE expression in mouse lung tissue extract.

RAGE (H-300) - sc-5563 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RAGE (H-300): sc-5563. Western blot analysis of RAGE expression in mouse lung extract.

Anti-RAGE antibody - ab3611 from Abcam

Prices $391.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RAGE antibody - ab54741 from Abcam

Prices $394.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab54741 RAGE antibody at 1ug/ml.

Anti-RAGE antibody - ab30381 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RAGE antibody (ab30381) at 1 µg/ml + Mouse Lung Whole Tissue Lysate at 20 µgSecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilutionPerformed under reducing conditions.

Anti-RAGE antibody - ab65965 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Rat lung tissue sections using ab65965 at 1µg/ml

Anti-RAGE antibody - ab20558 from Abcam

Host Goat
Clonality Polyclonal

Anti-RAGE antibody [8D11] - ab196511 from Abcam

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 8D11

Anti-RAGE antibody [EPR12205] - ab181369 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12205
All lanes : Anti-RAGE antibody [EPR12205] (ab181369) at 1/1000 dilutionLane 1 : Fetal lung lysateLane 2 : Mouse lung lysateLysates/proteins at 10 µg per lane.

Anti-RAGE antibody [EPR12206] - ab172473 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12206
All lanes : Anti-RAGE antibody [EPR12206] (ab172473) at 1/1000 dilutionLane 1 : Mouse lung lysateLane 2 : Rat lung lysateLane 3 : Human placenta lysateLysates/proteins at 10 µg per lane.

Anti-RAGE antibody [MM0520-8D11] - ab89911 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0520-8D11
Flow Cytometry analysis of human mesenchymal stem cells labelling RAGE with ab89911. A Phycoerythrin-conjugated F(ab′)2 goat anti-mouse IgG was used as secondary antibody. Histograms were set according to negative control stainings (#).

Anti-RAGE antibody - Azide free - ab87305 from Abcam

Prices $0.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-RAGE antibody - N-terminal - ab135513 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-RAGE antibody - N-terminal (ab135513) at 1/50 dilution + Mouse lung tissue lysate at 35 µgdeveloped using the ECL technique

Anti-AGER / RAGE Antibody (aa31-60) - LS-C319374 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AGER / RAGE Antibody (aa75-104) - LS-C330052 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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