AGER

Gene Symbol	AGER
Entrez Gene	177
Alt Symbol	RAGE
Species	Human
Gene Type	protein-coding
Description	advanced glycosylation end product-specific receptor
Other Description	RAGE isoform NtRAGE-delta|RAGE isoform sRAGE-delta|receptor for advanced glycation end-products variant 20
Swissprots	B0V176 Q9H2X7 Q9Y3R3 Q3L1R5 Q15279 A2BFI7 V5R6A3 Q3L1R4 A7Y2U9 Q3L1R8 Q15109 Q3L1R6 Q3L1R7 A6NKF0 Q86SN1 Q3L1S0
Accessions	AAB47491 AAD15888 AAD15889 AAG35728 BAA05958 CAA10169 CAB43094 CAK32486 EAX03610 EAX03611 Q15109 AB036432 BAA89369 AB061668 BAC65465 AB061669 BAC65466 AF536236 AAQ10685 AF536237 AAQ10686 AF537303 AAQ10782 AJ133822 CAB43108 AK298100 BAG60385 AK313178 BAG35995 AY755619 AAX07272 AY755620 AAX07273 AY755621 AAX07274 AY755622 AAX07275 AY755623 AAX07276 AY755624 AAX07277 AY755625 AAX07278 AY755626 AAX07279 AY755627 AAX07280 AY755628 AAX07281 BC020669 AAH20669 BM971899 DQ104251 AAZ32412 DQ104252 AAZ32413 DQ104253 AAZ32414 DQ104254 AAZ32415 DQ893575 ABM84501 DQ896821 ABM87820 EU117141 ABV03807 EU428811 ACE78167 EU428812 ACE78168 EU428813 ACE78169 EU428814 EU428815 ACE78170 EU428816 EU826616 ACF47652 EU826617 ACF47653 EU826618 ACF47654 EU826619 ACF47655 EU826620 ACF47656 FJ545655 ACL80027 GU139370 GU139371 ADQ42256 GU139372 GU139373 ADQ42257 GU139374 ADQ42258 GU139375 ADQ42259 GU139376 ADQ42260 GU139377 ADQ42261 GU139378 ADQ42262 GU139379 GU139380 GU139381 GU139382 GU139383 GU139384 HQ148133 ADV92535 HQ148134 ADV92536 HQ148135 ADV92537 KC692917 AHB30241 M91211 AAA03574 NM_001136 NP_001127 NM_001206929 NP_001193858 NM_001206932 NP_001193861 NM_001206934 NP_001193863 NM_001206936 NP_001193865 NM_001206940 NP_001193869 NM_001206954 NP_001193883 NM_001206966 NP_001193895 NM_172197 NP_751947 NR_038190
Function	Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular sp
Subcellular Location	Isoform 10: Cell membrane {ECO:0000269|PubMed:24260107}; Single-pass type I membrane protein {ECO:0000269|PubMed:24260107}.
Tissue Specificity	Endothelial cells.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RAGE full length protein - ab131756 from Abcam Category Protein Source Wheat germ Species Human

Human RAGE peptide - ab32414 from Abcam Category Peptide

Human RAGE protein fragment - ab63271 from Abcam Category Protein Source E. coli Species Human

Human RAGE protein fragment - ab117470 from Abcam Category Protein Source HEK 293 cells Species Human

RAGE peptide - ab49418 from Abcam Category Peptide

Rat RAGE peptide - ab41778 from Abcam Category Peptide Species Rat

AGER / RAGE Antibody Blocking Peptide - LS-E7618 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AGER / RAGE Antibody Blocking Peptide - LS-E6947 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AGER / RAGE Antibody Blocking Peptide - LS-E15327 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AGER / RAGE Antibody Blocking Peptide - LS-E15262 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human AGER Protein - H00000177-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human AGER Protein - H00000177-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

AGER Peptide - P1072 from Novus Biologicals Category Peptide Species Human

RAGE-AGER-Antibody-N-term-Blocking-peptide - BP2401a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AGER-Antibody-N-term-Blocking-Peptide - BP4861a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human RAGE Fc Chimera, CF - 1145-RG-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Mouse RAGE Fc Chimera, CF - 1179-RG-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant human Advanced glycosylation end product-specific receptor (OPCA01017) - OPCA01017 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

sRAGE Protein (OPPA01766) - OPPA01766 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

sRAGE Protein (OPPA01767) - OPPA01767 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source HEK293 (Human Embryonic Kidney Cell Line)

Human Advanced Glycosylation End Product-Specific Receptor protein - orb81387 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

Human AGE protein - orb245582 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human AGER Protein - abx065184 from Abbexa Category Protein Source E.coli Species Human

RAGE / AGER - H00000177-H01 from Acris Antibodies Category Protein Prices $770.00 Sizes 25 µg Source Human HEK293T cells Species Human

RAGE / AGER - H00000177-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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