AGER

Gene Symbol AGER
Entrez Gene 177
Alt Symbol RAGE
Species Human
Gene Type protein-coding
Description advanced glycosylation end product-specific receptor
Other Description RAGE isoform NtRAGE-delta|RAGE isoform sRAGE-delta|receptor for advanced glycation end-products variant 20
Swissprots B0V176 Q9H2X7 Q9Y3R3 Q3L1R5 Q15279 A2BFI7 V5R6A3 Q3L1R4 A7Y2U9 Q3L1R8 Q15109 Q3L1R6 Q3L1R7 A6NKF0 Q86SN1 Q3L1S0
Accessions AAB47491 AAD15888 AAD15889 AAG35728 BAA05958 CAA10169 CAB43094 CAK32486 EAX03610 EAX03611 Q15109 AB036432 BAA89369 AB061668 BAC65465 AB061669 BAC65466 AF536236 AAQ10685 AF536237 AAQ10686 AF537303 AAQ10782 AJ133822 CAB43108 AK298100 BAG60385 AK313178 BAG35995 AY755619 AAX07272 AY755620 AAX07273 AY755621 AAX07274 AY755622 AAX07275 AY755623 AAX07276 AY755624 AAX07277 AY755625 AAX07278 AY755626 AAX07279 AY755627 AAX07280 AY755628 AAX07281 BC020669 AAH20669 BM971899 DQ104251 AAZ32412 DQ104252 AAZ32413 DQ104253 AAZ32414 DQ104254 AAZ32415 DQ893575 ABM84501 DQ896821 ABM87820 EU117141 ABV03807 EU428811 ACE78167 EU428812 ACE78168 EU428813 ACE78169 EU428814 EU428815 ACE78170 EU428816 EU826616 ACF47652 EU826617 ACF47653 EU826618 ACF47654 EU826619 ACF47655 EU826620 ACF47656 FJ545655 ACL80027 GU139370 GU139371 ADQ42256 GU139372 GU139373 ADQ42257 GU139374 ADQ42258 GU139375 ADQ42259 GU139376 ADQ42260 GU139377 ADQ42261 GU139378 ADQ42262 GU139379 GU139380 GU139381 GU139382 GU139383 GU139384 HQ148133 ADV92535 HQ148134 ADV92536 HQ148135 ADV92537 KC692917 AHB30241 M91211 AAA03574 NM_001136 NP_001127 NM_001206929 NP_001193858 NM_001206932 NP_001193861 NM_001206934 NP_001193863 NM_001206936 NP_001193865 NM_001206940 NP_001193869 NM_001206954 NP_001193883 NM_001206966 NP_001193895 NM_172197 NP_751947 NR_038190
Function Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular sp
Subcellular Location Isoform 10: Cell membrane {ECO:0000269|PubMed:24260107}; Single-pass type I membrane protein {ECO:0000269|PubMed:24260107}.
Tissue Specificity Endothelial cells.

RAGE CRISPR/Cas9 KO Plasmid (h) - sc-400284 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAGE HDR Plasmid (h) - sc-400284-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAGE Double Nickase Plasmid (h) - sc-400284-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAGE Double Nickase Plasmid (h2) - sc-400284-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAGE CRISPR Activation Plasmid (h) - sc-400284-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAGE CRISPR Activation Plasmid (h2) - sc-400284-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAGE Lentiviral Activation Particles (h) - sc-400284-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAGE Lentiviral Activation Particles (h2) - sc-400284-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAGE siRNA (h) - sc-36374 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RAGE shRNA Plasmid (h) - sc-36374-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RAGE shRNA (h) Lentiviral Particles - sc-36374-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AGER RNAi - H00000177-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN2941 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2941 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01051 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01051

AGER siRNA (Human) - CRH0125 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AGER RNAi - H00000177-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

AGER - MBS8203250 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human AGER (NM_001136.4) - SHH233230 from Creative biogene

Category siRNA
Species Reactivities Human

RAGE CRISPR/Cas9 KO Plasmid (h2) - sc-400284-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAGE HDR Plasmid (h2) - sc-400284-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Human AGER siRNA - orb260627 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AGER shRNA Plasmid (Human) - CHH0125 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

AGER miRNA 3'UTR clone - MiUTR4H-TG00208 from Creative biogene

Species Reactivities Human
Search more