| Gene Symbol |
HOOK1
|
| Entrez Gene |
51361
|
| Alt Symbol |
HK1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hook microtubule-tethering protein 1
|
| Other Description |
h-hook1|hHK1|hook homolog 1|protein Hook homolog 1
|
| Swissprots |
A8MU44 Q5TG44 O60561 B4DX15 Q9UJC3 A8K8E9
|
| Accessions |
EAX06615 EAX06616 Q9UJC3 AA576610 AF044923 AAC09298 AK027250 AK097735 AK098561 AK292314 BAF85003 AK301768 BAG63227 BC011621 AAH11621 BC107857 AAI07858 DQ891957 ABM82883 DQ895143 ABM86069 XM_006710676 XP_006710739 XM_011541562 XP_011539864 XM_011541563 XP_011539865 XR_246271 XR_946665 NM_015888 NP_056972
|
| Function |
Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:11238449}. Note=Localizes to the spermatid manchette during spermiogenesis but is not present in mature spermatozoa (By similarity). Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules. {ECO:0000250}.
|