Gene Symbol | HOOK1 |
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Entrez Gene | 51361 |
Alt Symbol | HK1 |
Species | Human |
Gene Type | protein-coding |
Description | hook microtubule-tethering protein 1 |
Other Description | h-hook1|hHK1|hook homolog 1|protein Hook homolog 1 |
Swissprots | A8MU44 Q5TG44 O60561 B4DX15 Q9UJC3 A8K8E9 |
Accessions | EAX06615 EAX06616 Q9UJC3 AA576610 AF044923 AAC09298 AK027250 AK097735 AK098561 AK292314 BAF85003 AK301768 BAG63227 BC011621 AAH11621 BC107857 AAI07858 DQ891957 ABM82883 DQ895143 ABM86069 XM_006710676 XP_006710739 XM_011541562 XP_011539864 XM_011541563 XP_011539865 XR_246271 XR_946665 NM_015888 NP_056972 |
Function | Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:11238449}. Note=Localizes to the spermatid manchette during spermiogenesis but is not present in mature spermatozoa (By similarity). Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules. {ECO:0000250}. |
HOOK1 CRISPR/Cas9 KO Plasmid (h) - sc-404872 from Santa Cruz Biotechnology
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HOOK1 HDR Plasmid (h) - sc-404872-HDR from Santa Cruz Biotechnology
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HOOK1 Double Nickase Plasmid (h) - sc-404872-NIC from Santa Cruz Biotechnology
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HOOK1 Double Nickase Plasmid (h2) - sc-404872-NIC-2 from Santa Cruz Biotechnology
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HOOK1 CRISPR Activation Plasmid (h) - sc-404872-ACT from Santa Cruz Biotechnology
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HOOK1 CRISPR Activation Plasmid (h2) - sc-404872-ACT-2 from Santa Cruz Biotechnology
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HOOK1 Lentiviral Activation Particles (h) - sc-404872-LAC from Santa Cruz Biotechnology
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HOOK1 Lentiviral Activation Particles (h2) - sc-404872-LAC-2 from Santa Cruz Biotechnology
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HOOK1 siRNA (h) - sc-60796 from Santa Cruz Biotechnology
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HOOK1 shRNA Plasmid (h) - sc-60796-SH from Santa Cruz Biotechnology
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HOOK1 shRNA (h) Lentiviral Particles - sc-60796-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU042451 from Sigma-Aldrich
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MISSION® esiRNA - EHU103461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10221 from Sigma-Aldrich
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HOOK1 siRNA (Human) - CRH9720 from Cohesion Biosciences
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HOOK1 RNAi - H00051361-R01 from Novus Biologicals
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HOOK1 - MBS8229741 from MyBioSource
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shRNA set against Human HOOK1 (NM_015888.4) - SHH313997 from Creative biogene
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shRNA set against Human HOOK1(NM_015888.4) - SHH128045 from Creative biogene
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HOOK1 shRNA Plasmid (Human) - CHH9720 from Cohesion Biosciences
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HOOK1 miRNA 3'UTR clone - MiUTR1H-04645 from Creative biogene
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