| Gene Symbol |
TTF1
|
| Entrez Gene |
7270
|
| Alt Symbol |
TTF-1, TTF-I
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription termination factor, RNA polymerase I
|
| Other Description |
transcription termination factor 1
|
| Swissprots |
Q58EY2 Q6P5T5 Q15361 Q4VXF3 A1L160
|
| Accessions |
EAW88001 EAW88002 Q15361 AK225119 AK302902 BAG64074 BC050734 AAH50734 BC062692 AAH62692 BC104639 AAI04640 BC127669 AAI27670 BC127670 AAI27671 BC143048 AAI43049 BC143049 AAI43050 BC143821 BC167784 AAI67784 BM827593 BP209178 BU195816 BU674009 XM_006717273 XP_006717336 XR_246601 XR_929838 NM_001205296 NP_001192225 NM_007344 NP_031370
|
| Function |
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000269|PubMed:7597036}.
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus {ECO:0000250}.
|
| Top Pathways |
Thyroid hormone synthesis
|