Gene Symbol | TTF1 |
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Entrez Gene | 7270 |
Alt Symbol | TTF-1, TTF-I |
Species | Human |
Gene Type | protein-coding |
Description | transcription termination factor, RNA polymerase I |
Other Description | transcription termination factor 1 |
Swissprots | Q58EY2 Q6P5T5 Q15361 Q4VXF3 A1L160 |
Accessions | EAW88001 EAW88002 Q15361 AK225119 AK302902 BAG64074 BC050734 AAH50734 BC062692 AAH62692 BC104639 AAI04640 BC127669 AAI27670 BC127670 AAI27671 BC143048 AAI43049 BC143049 AAI43050 BC143821 BC167784 AAI67784 BM827593 BP209178 BU195816 BU674009 XM_006717273 XP_006717336 XR_246601 XR_929838 NM_001205296 NP_001192225 NM_007344 NP_031370 |
Function | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000269|PubMed:7597036}. |
Subcellular Location | Nucleus. Nucleus, nucleolus {ECO:0000250}. |
Top Pathways | Thyroid hormone synthesis |
TTF CRISPR/Cas9 KO Plasmid (h) - sc-407927 from Santa Cruz Biotechnology
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TTF HDR Plasmid (h) - sc-407927-HDR from Santa Cruz Biotechnology
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TTF Double Nickase Plasmid (h) - sc-407927-NIC from Santa Cruz Biotechnology
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TTF Double Nickase Plasmid (h2) - sc-407927-NIC-2 from Santa Cruz Biotechnology
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TTF CRISPR Activation Plasmid (h) - sc-407927-ACT from Santa Cruz Biotechnology
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TTF CRISPR Activation Plasmid (h2) - sc-407927-ACT-2 from Santa Cruz Biotechnology
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TTF Lentiviral Activation Particles (h) - sc-407927-LAC from Santa Cruz Biotechnology
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TTF Lentiviral Activation Particles (h2) - sc-407927-LAC-2 from Santa Cruz Biotechnology
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TTF siRNA (h) - sc-38602 from Santa Cruz Biotechnology
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TTF shRNA Plasmid (h) - sc-38602-SH from Santa Cruz Biotechnology
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TTF shRNA (h) Lentiviral Particles - sc-38602-V from Santa Cruz Biotechnology
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RNA polymerase I termination factor RNAi - H00007270-R01 from Novus Biologicals
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MISSION® esiRNA - EHU149411 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22190 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22190 from Sigma-Aldrich
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TTF1 siRNA (Human) - CRH4969 from Cohesion Biosciences
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TTF1 - MBS8233317 from MyBioSource
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shRNA set against Human Ttf1 (NM_007344.3) - SHH437269 from Creative biogene
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Human TTF1 siRNA - orb265471 from Biorbyt
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TTF1 shRNA Plasmid (Human) - CHH4969 from Cohesion Biosciences
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TTF1 miRNA 3'UTR clone - MiUTR3H-03623 from Creative biogene
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