Gene Symbol | TTF1 |
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Entrez Gene | 7270 |
Alt Symbol | TTF-1, TTF-I |
Species | Human |
Gene Type | protein-coding |
Description | transcription termination factor, RNA polymerase I |
Other Description | transcription termination factor 1 |
Swissprots | Q58EY2 Q6P5T5 Q15361 Q4VXF3 A1L160 |
Accessions | EAW88001 EAW88002 Q15361 AK225119 AK302902 BAG64074 BC050734 AAH50734 BC062692 AAH62692 BC104639 AAI04640 BC127669 AAI27670 BC127670 AAI27671 BC143048 AAI43049 BC143049 AAI43050 BC143821 BC167784 AAI67784 BM827593 BP209178 BU195816 BU674009 XM_006717273 XP_006717336 XR_246601 XR_929838 NM_001205296 NP_001192225 NM_007344 NP_031370 |
Function | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000269|PubMed:7597036}. |
Subcellular Location | Nucleus. Nucleus, nucleolus {ECO:0000250}. |
Top Pathways | Thyroid hormone synthesis |
Human Transcription termination factor 1 protein fragment - ab159754 from Abcam
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NKX2-1 / Thyroid-Specific TF Antibody Blocking Peptide - LS-E450 from LifeSpan Bioscience
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NKX2-1 / Thyroid-Specific TF Antibody Blocking Peptide - LS-E5337 from LifeSpan Bioscience
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NKX2-1 / Thyroid-Specific TF Antibody Blocking Peptide - LS-E31236 from LifeSpan Bioscience
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TTF1 / Txn Termination Factor Antibody Blocking Peptide - LS-E22396 from LifeSpan Bioscience
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TTF1 / Txn Termination Factor Antibody Blocking Peptide - LS-E13271 from LifeSpan Bioscience
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Recombinant Human RNA polymerase I termination factor Protein - H00007270-Q01 from Novus Biologicals
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TTF-1-Antibody-N-term-Blocking-peptide - BP12764a from Abgent, a WuXi AppTec company
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Recombinant human Transcription termination factor 1 (OPCA00935) - OPCA00935 from Aviva Systems Biology
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Human TTF1 protein - orb245516 from Biorbyt
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TTF1 - H00007270-Q01-10 from Acris Antibodies
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TTF1 - H00007270-Q01-25 from Acris Antibodies
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Recombinant Transcription Termination Factor, RNA polymerase I (TTF1) - RPG777Hu01 from Uscn Life Science Inc.
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TTF-1 (V27) Peptide - BS2947P from Bioworld Technology
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Recombinant Transcription Termination Factor, RNA polymerase I (TTF1) - RPG777Hu01 from Cloud-clone
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Recombinant Thyroid Transcription Factor 1 (TITF1) - RPG782Hu01 from Cloud-clone
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Recombinant human Transcription termination factor 1 - CSB-EP116774h(N) CSB-BP116774h(N) CSB-MP116774h(N) from Cusabio
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Recombinant Human Transcription termination factor 1(TTF1),partial - CSB-RP116774h(N) from Cusabio
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Recombinant Human Transcription termination factor 1(TTF1) ,partial - CSB-YP622994HU CSB-EP622994HU CSB-BP622994HU CSB-MP622994HU from Cusabio
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TTF1 Blocking Peptide - CBP4301 from Cohesion Biosciences
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Transcription termination factor 1 - RPC141270 from Biomatik
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Transcription Termination Factor, RNA polymerase I Protein (Recombinant) - abx168208 from Abbexa
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TTF1 Blocking Peptide - abx161512 from Abbexa
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RNA polymerase I termination factor Recombinant Protein Antigen - NBP2-38740PEP from Novus Biologicals
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TTF-1 protein - orb86069 from Biorbyt
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