Gene Symbol | TTF1 |
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Entrez Gene | 7270 |
Alt Symbol | TTF-1, TTF-I |
Species | Human |
Gene Type | protein-coding |
Description | transcription termination factor, RNA polymerase I |
Other Description | transcription termination factor 1 |
Swissprots | Q58EY2 Q6P5T5 Q15361 Q4VXF3 A1L160 |
Accessions | EAW88001 EAW88002 Q15361 AK225119 AK302902 BAG64074 BC050734 AAH50734 BC062692 AAH62692 BC104639 AAI04640 BC127669 AAI27670 BC127670 AAI27671 BC143048 AAI43049 BC143049 AAI43050 BC143821 BC167784 AAI67784 BM827593 BP209178 BU195816 BU674009 XM_006717273 XP_006717336 XR_246601 XR_929838 NM_001205296 NP_001192225 NM_007344 NP_031370 |
Function | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000269|PubMed:7597036}. |
Subcellular Location | Nucleus. Nucleus, nucleolus {ECO:0000250}. |
Top Pathways | Thyroid hormone synthesis |
TTF (24) - sc-136371 from Santa Cruz Biotechnology
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TTF (N-20) - sc-17694 from Santa Cruz Biotechnology
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Anti-Transcription termination factor 1 antibody - ab87726 from Abcam
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Anti-TTF1 / Txn Termination Factor Antibody (aa138-286) - LS-C189260 from LifeSpan Bioscience
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Anti-TTF1 / Txn Termination Factor Antibody - LS-C285718 from LifeSpan Bioscience
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Anti-TTF1 / Txn Termination Factor Antibody (aa10-59) - LS-C291263 from LifeSpan Bioscience
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Anti-TTF1 / Txn Termination Factor Antibody (Biotin) - LS-C316567 from LifeSpan Bioscience
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Anti-TTF1 / Txn Termination Factor Antibody (HRP) - LS-C316571 from LifeSpan Bioscience
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Anti-TTF1 / Txn Termination Factor Antibody (FITC) - LS-C318690 from LifeSpan Bioscience
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Anti-TTF1 / Txn Termination Factor Antibody (aa412-461) - LS-C135949 from LifeSpan Bioscience
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Anti-NKX2-1 / Thyroid-Specific TF Antibody (clone 8G7G3/1) - LS-C312196 from LifeSpan Bioscience
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Anti-TTF1 / Txn Termination Factor Antibody (aa1-50) - LS-C289111 from LifeSpan Bioscience
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Anti-TTF1 / Txn Termination Factor Antibody (aa51-100) IHC-plus⢠- LS-B5631 from LifeSpan Bioscience
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RNA polymerase I termination factor Antibody - NBP2-38740 from Novus Biologicals
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TTF1 / NKX2.1 Antibody - NBP1-19719 from Novus Biologicals
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TTF1 / NKX2.1 Antibody (C12-I) - NBP1-79057 from Novus Biologicals
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TTF1 / NKX2.1 Antibody (G21-G) - NBP1-79056 from Novus Biologicals
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RNA polymerase I termination factor Antibody - NBP1-74129 from Novus Biologicals
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TTF1 / NKX2.1 Antibody (SPM150) [DyLight 405LS] - NBP2-34742V3 from Novus Biologicals
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TTF1 / NKX2.1 Antibody (SPM150) [HRP] - NBP2-34742H from Novus Biologicals
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TTF1 / NKX2.1 Antibody (SPM150) [DyLight 488] - NBP2-34742G from Novus Biologicals
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TTF1 / NKX2.1 Antibody (SPM150) [DyLight 680] - NBP2-34742FR from Novus Biologicals
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TTF1 / NKX2.1 Antibody (SPM150) [DyLight 650] - NBP2-34742C from Novus Biologicals
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TTF1 / NKX2.1 Antibody (SPM150) [Biotin] - NBP2-34742B from Novus Biologicals
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TTF1 / NKX2.1 Antibody (SPM150) [Allophycocyanin] - NBP2-34742APC from Novus Biologicals
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