| Gene Symbol |
NOP10
|
| Entrez Gene |
55505
|
| Alt Symbol |
DKCB1, NOLA3, NOP10P
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NOP10 ribonucleoprotein
|
| Other Description |
H/ACA ribonucleoprotein complex subunit 3|NOP10 ribonucleoprotein homolog|homolog of yeast Nop10p|nucleolar protein 10|nucleolar protein family A member 3|nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs)|snoRNP protein NOP10
|
| Swissprots |
Q9NPE3
|
| Accessions |
BAA96107 CBG17030 CBV30476 EAW92303 Q9NPE3 AB043104 BAA96133 BC008886 AAH08886 BC063023 AAH63023 BM554889 BQ218536 NM_018648 NP_061118
|
| Function |
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269|PubMed:15044956}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:11074001}. Nucleus, Cajal body {ECO:0000269|PubMed:11074001}. Note=Also localized to Cajal bodies (coiled bodies).
|
| Top Pathways |
Ribosome biogenesis in eukaryotes
|