Gene Symbol | NOP10 |
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Entrez Gene | 55505 |
Alt Symbol | DKCB1, NOLA3, NOP10P |
Species | Human |
Gene Type | protein-coding |
Description | NOP10 ribonucleoprotein |
Other Description | H/ACA ribonucleoprotein complex subunit 3|NOP10 ribonucleoprotein homolog|homolog of yeast Nop10p|nucleolar protein 10|nucleolar protein family A member 3|nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs)|snoRNP protein NOP10 |
Swissprots | Q9NPE3 |
Accessions | BAA96107 CBG17030 CBV30476 EAW92303 Q9NPE3 AB043104 BAA96133 BC008886 AAH08886 BC063023 AAH63023 BM554889 BQ218536 NM_018648 NP_061118 |
Function | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269|PubMed:15044956}. |
Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:11074001}. Nucleus, Cajal body {ECO:0000269|PubMed:11074001}. Note=Also localized to Cajal bodies (coiled bodies). |
Top Pathways | Ribosome biogenesis in eukaryotes |
Nop10 (D-12) - sc-104461 from Santa Cruz Biotechnology
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Nop10 (H-54) - sc-292092 from Santa Cruz Biotechnology
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Nop10 (S-12) - sc-104462 from Santa Cruz Biotechnology
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Anti-NOP10 antibody - ab99084 from Abcam
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Anti-NOP10 antibody [EPR8856] - ab133726 from Abcam
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Anti-NOP10 antibody [EPR8857] - ab134902 from Abcam
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Anti-NOP10 Antibody (N-Terminus) - LS-C112016 from LifeSpan Bioscience
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Anti-NOP10 Antibody (Internal, clone EPR8856) - LS-C154641 from LifeSpan Bioscience
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Anti-NOP10 Antibody (C-Terminus, clone EPR8857) IHC-plus™ - LS-B10969 from LifeSpan Bioscience
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NOP10 Antibody - NBP2-32441 from Novus Biologicals
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NOP10 Antibody - NBP1-56381 from Novus Biologicals
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NOP10 Antibody (6H6) - H00055505-M01-100ug from Novus Biologicals
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Monoclonal Anti-NOP10 antibody produced in mouse - SAB1412849 from Sigma-Aldrich
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Anti-NOLA3 antibody produced in rabbit - SAB2106085 from Sigma-Aldrich
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Anti-NOP10 antibody produced in rabbit - HPA059198 from Sigma-Aldrich
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NOLA3 antibody - middle region (ARP57279_P050) - ARP57279_P050 from Aviva Systems Biology
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NOLA3 antibody, Internal - GTX44934 from GeneTex
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NOLA3 antibody - 70R-3305 from Fitzgerald
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NOLA3 antibody - H00055505-M01 from Acris Antibodies
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NOLA3 Antibody - GWB-MU756I from Genway Biotech
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Nop10 - MBS647684 from MyBioSource
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Rabbit Anti-Human NOP10 Polyclonal Antibody - DPABH-19928 from Creative Diagnostics
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NOLA3, Polyclonal Antibody - MBS5302160 from MyBioSource
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Nop10 (6H6) - sc-517170 from Santa Cruz Biotechnology
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NOLA3 antibody - TA344845 from Acris Antibodies
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