SHC1

Gene Symbol	SHC1
Entrez Gene	6464
Alt Symbol	SHC, SHCA
Species	Human
Gene Type	protein-coding
Description	SHC (Src homology 2 domain containing) transforming protein 1
Other Description	SH2 domain protein C1|SHC (Src homology 2 domain-containing) transforming protein 1|SHC-transforming protein 1|SHC-transforming protein 3|SHC-transforming protein A
Swissprots	Q96CL1 Q5T184 O15290 Q8N4K5 Q5T180 P29353 Q5T185 B5BU19 D3DV78 Q5T183 Q5T186
Accessions	AAM61859 AAM61860 CAA70977 EAW53167 EAW53168 EAW53169 EAW53170 EAW53171 P29353 AB208849 BAD92086 AB451255 BAG70069 AB451379 BAG70193 AK096169 AK130014 AK225332 AK292143 BAF84832 AK296786 BAG59364 AK315842 BAF98733 BC011813 BC014158 AAH14158 BC017283 BC033925 AAH33925 BX647136 BX647149 HQ448284 ADQ32764 U73377 AAB49972 X68148 CAA48251 XM_005245449 XP_005245506 XM_005245451 XP_005245508 XM_011509892 XP_011508194 XM_011509893 XP_011508195 XM_011509894 XP_011508196 XM_011509895 XP_011508197 XM_011509896 XP_011508198 XM_011509897 XP_011508199 XM_011509898 XP_011508200 NM_001130040 NP_001123512 NM_001130041 NP_001123513 NM_001202859 NP_001189788 NM_003029 NP_003020 NM_183001 NP_892113
Function	Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in s
Subcellular Location	Isoform p66Shc: Mitochondrion {ECO:0000250}. Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation. {ECO:0000250}.
Tissue Specificity	Widely expressed. Expressed in neural stem cells but absent in mature neurons.
Top Pathways	Natural killer cell mediated cytotoxicity, Estrogen signaling pathway, Chronic myeloid leukemia, MicroRNAs in cancer, Insulin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SHC-transforming protein 1 (SHC1), Human, ELISA Kit - CSB-EL021253HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

SHC-Transforming Protein 1 (SHC1), Human, ELISA Kit - SEE671Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.117ng/mL Range 0.312-20ng/mL

SH2-Containing Protein, SHC/SLP-76, Human, ELISA Kit - E-EL-H0929 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

SH2-Containing Protein, SHC/SLP-76, Rabbit, ELISA Kit - E-EL-RB1931 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

SH2-Containing Protein, SHC/SLP-76, Chicken, ELISA Kit - E-EL-Ch1345 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

SH2-Containing Protein, SHC/SLP-76, Porcine, ELISA Kit - E-EL-P1914 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

SH2-Containing Protein, SHC/SLP-76, Sheep, ELISA Kit - E-EL-S0735 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

SH2-Containing Protein, SHC/SLP-76, Monkey, ELISA Kit - E-EL-MK0032 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

SHC-Transforming Protein 1 (SHC1), ELISA Kit - MBS2019597 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.117ng/mL. Range 0.313-20ng/mL

SHC/SLP-76, ELISA Kit - MBS2502154 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

Shc Colorimetric Cell-Based ELISA Kit - CB5628 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Shc (Phospho-Tyr349) Colorimetric Cell-Based ELISA Kit - CBP1023 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Shc (Phospho-Tyr427) Colorimetric Cell-Based ELISA Kit - CBP1024 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human SHC/SLP-76(SH2-Containing Protein) ELISA Kit - E-EL-H0929 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

SHC (Src homology 2 domain containing) transforming protein 1, ELISA Kit - MBS946428 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 6.25 pg/ml. Range 25 pg/ml-1600 pg/ml.

ELISA Kit for SHC-Transforming Protein 1 (SHC1) - SEE671Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.117ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human SHC-transforming protein 1(SHC1) ELISA kit - CSB-EL021253HU from Cusabio Category ELISA Kit Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

ELISA Kit for SHC-Transforming Protein 1 (SHC1) - SEE671Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.117ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human SHC/SLP-76(SH2-Containing Protein) ELISA Kit - E-EL-H0929 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mLng/mL Range 0.16~10 ng/mL

Human SHC1 ELISA Kit - abx153080 from Abbexa Category ELISA Kit Sensitivity 0.117 ng/ml Range 0.313 ng/ml - 20 ng/ml

SHC-Transforming Protein 1 (SHC1), Human, ELISA Kit - DL-SHC1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Shc ELISA Kit - DEIA-XYA1610 from Creative Diagnostics Category ELISA Kit

Shc (Phospho-Tyr349) ELISA Kit - DEIA-XYA1611 from Creative Diagnostics Category ELISA Kit

Shc (Phospho-Tyr427) ELISA Kit - DEIA-XYA1612 from Creative Diagnostics Category ELISA Kit

Human SHC1 ELISA Kit - abx572807 from Abbexa Category ELISA Kit Sensitivity 0.117 ng/ml Range 0.313 ng/ml - 20 ng/ml

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