SHC1
| Gene Symbol | SHC1 |
|---|---|
| Entrez Gene | 6464 |
| Alt Symbol | SHC, SHCA |
| Species | Human |
| Gene Type | protein-coding |
| Description | SHC (Src homology 2 domain containing) transforming protein 1 |
| Other Description | SH2 domain protein C1|SHC (Src homology 2 domain-containing) transforming protein 1|SHC-transforming protein 1|SHC-transforming protein 3|SHC-transforming protein A |
| Swissprots | Q96CL1 Q5T184 O15290 Q8N4K5 Q5T180 P29353 Q5T185 B5BU19 D3DV78 Q5T183 Q5T186 |
| Accessions | AAM61859 AAM61860 CAA70977 EAW53167 EAW53168 EAW53169 EAW53170 EAW53171 P29353 AB208849 BAD92086 AB451255 BAG70069 AB451379 BAG70193 AK096169 AK130014 AK225332 AK292143 BAF84832 AK296786 BAG59364 AK315842 BAF98733 BC011813 BC014158 AAH14158 BC017283 BC033925 AAH33925 BX647136 BX647149 HQ448284 ADQ32764 U73377 AAB49972 X68148 CAA48251 XM_005245449 XP_005245506 XM_005245451 XP_005245508 XM_011509892 XP_011508194 XM_011509893 XP_011508195 XM_011509894 XP_011508196 XM_011509895 XP_011508197 XM_011509896 XP_011508198 XM_011509897 XP_011508199 XM_011509898 XP_011508200 NM_001130040 NP_001123512 NM_001130041 NP_001123513 NM_001202859 NP_001189788 NM_003029 NP_003020 NM_183001 NP_892113 |
| Function | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in s |
| Subcellular Location | Isoform p66Shc: Mitochondrion {ECO:0000250}. Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation. {ECO:0000250}. |
| Tissue Specificity | Widely expressed. Expressed in neural stem cells but absent in mature neurons. |
| Top Pathways | Natural killer cell mediated cytotoxicity, Estrogen signaling pathway, Chronic myeloid leukemia, MicroRNAs in cancer, Insulin signaling pathway |
Shc CRISPR/Cas9 KO Plasmid (h) - sc-400914 from Santa Cruz Biotechnology
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Shc HDR Plasmid (h) - sc-400914-HDR from Santa Cruz Biotechnology
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Shc Double Nickase Plasmid (h) - sc-400914-NIC from Santa Cruz Biotechnology
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Shc Double Nickase Plasmid (h2) - sc-400914-NIC-2 from Santa Cruz Biotechnology
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Shc CRISPR Activation Plasmid (h) - sc-400914-ACT from Santa Cruz Biotechnology
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Shc CRISPR Activation Plasmid (h2) - sc-400914-ACT-2 from Santa Cruz Biotechnology
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Shc Lentiviral Activation Particles (h) - sc-400914-LAC from Santa Cruz Biotechnology
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Shc Lentiviral Activation Particles (h2) - sc-400914-LAC-2 from Santa Cruz Biotechnology
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Shc siRNA (h) - sc-29480 from Santa Cruz Biotechnology
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Shc shRNA Plasmid (h) - sc-29480-SH from Santa Cruz Biotechnology
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Shc shRNA (h) Lentiviral Particles - sc-29480-V from Santa Cruz Biotechnology
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SHC1 RNAi - H00006464-R01 from Novus Biologicals
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MISSION® esiRNA - EHU085221 from Sigma-Aldrich
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SHC1 siRNA (Human) - CRH4370 from Cohesion Biosciences
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SHC1 RNAi - H00006464-R02 from Novus Biologicals
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SHC1 - MBS8205084 from MyBioSource
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shRNA set against Human SHC1 (NM_003029.4) - SHH406964 from Creative biogene
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shRNA set against Human SHC1(NM_183001.4) - SHR224016 from Creative biogene
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Human SHC1 siRNA - orb264872 from Biorbyt
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SHC1 shRNA Plasmid (Human) - CHH4370 from Cohesion Biosciences
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SHC1 miRNA 3'UTR clone - MiUTR1H-09374 from Creative biogene
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SHC1 miRNA 3'UTR clone - MiUTR1H-09375 from Creative biogene
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SHC1 miRNA 3'UTR clone - MiUTR1H-09376 from Creative biogene
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SHC1 miRNA 3'UTR clone - MiUTR3H-03476 from Creative biogene
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