SHC1

Gene Symbol	SHC1
Entrez Gene	6464
Alt Symbol	SHC, SHCA
Species	Human
Gene Type	protein-coding
Description	SHC (Src homology 2 domain containing) transforming protein 1
Other Description	SH2 domain protein C1|SHC (Src homology 2 domain-containing) transforming protein 1|SHC-transforming protein 1|SHC-transforming protein 3|SHC-transforming protein A
Swissprots	Q96CL1 Q5T184 O15290 Q8N4K5 Q5T180 P29353 Q5T185 B5BU19 D3DV78 Q5T183 Q5T186
Accessions	AAM61859 AAM61860 CAA70977 EAW53167 EAW53168 EAW53169 EAW53170 EAW53171 P29353 AB208849 BAD92086 AB451255 BAG70069 AB451379 BAG70193 AK096169 AK130014 AK225332 AK292143 BAF84832 AK296786 BAG59364 AK315842 BAF98733 BC011813 BC014158 AAH14158 BC017283 BC033925 AAH33925 BX647136 BX647149 HQ448284 ADQ32764 U73377 AAB49972 X68148 CAA48251 XM_005245449 XP_005245506 XM_005245451 XP_005245508 XM_011509892 XP_011508194 XM_011509893 XP_011508195 XM_011509894 XP_011508196 XM_011509895 XP_011508197 XM_011509896 XP_011508198 XM_011509897 XP_011508199 XM_011509898 XP_011508200 NM_001130040 NP_001123512 NM_001130041 NP_001123513 NM_001202859 NP_001189788 NM_003029 NP_003020 NM_183001 NP_892113
Function	Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in s
Subcellular Location	Isoform p66Shc: Mitochondrion {ECO:0000250}. Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation. {ECO:0000250}.
Tissue Specificity	Widely expressed. Expressed in neural stem cells but absent in mature neurons.
Top Pathways	Natural killer cell mediated cytotoxicity, Estrogen signaling pathway, Chronic myeloid leukemia, MicroRNAs in cancer, Insulin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SHC protein fragment - ab109851 from Abcam Category Protein Source E. coli Species Human

SHC1 Partial Recombinant Protein - H00006464-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human SHC1 Protein - NBP1-72374 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

SHC1 Recombinant Protein - P3720 from Novus Biologicals Category Protein Prices $549.00 Sizes 100 µg Species Human

SHC-Antibody-Y427-Blocking-Peptide - BP7762d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SHC-Antibody-N-term-Blocking-Peptide - BP7762a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human SHC1 protein - orb169292 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

SHC1 Blocking Peptide - 33R-1145 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SHC1 protein (His tag) - 80R-1884 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

SHC1 / SHC (1-474, His-tag) - AR39068PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

SHC1 / SHC (1-474, His-tag) - AR39068PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

SHC1 / SHC - H00006464-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SHC1 / SHC - H00006464-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SHC1 / SHC - P3720 from Acris Antibodies Category Protein Prices $500.00 Sizes 100 µg Species Human

SHC1 / SHC control peptide - AP10318CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

SHC1, 1-474aa, Human, His tag, E.coli - 01-P1128 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

SHC1 fusion protein - ag0103 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SHC1 fusion protein - ag3165 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SHC1 Human - PRPS-890 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human SHC1 Protein - BP002275-PRO-883 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

SHC1, 1-474aa, Recombinant Protein - GWB-P0910M from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human SHC1, His-tagged - SHC1-3579H from Creative Biomart Category Protein

Recombinant Human SHC1, His-tagged - SHC1-30065TH from Creative Biomart Category Protein Source E. coli

Recombinant Human SHC1, GST-tagged - SHC1-2654H from Creative Biomart Category Protein Source E.coli Species Human

SHC1 1-474aa - CMB-961 from Reagent Proteins Category Protein Prices $469.00, $889.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

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