| Gene Symbol | CYP17A1 |
|---|---|
| Entrez Gene | 1586 |
| Alt Symbol | CPT7, CYP17, P450C17, S17AH |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytochrome P450, family 17, subfamily A, polypeptide 1 |
| Other Description | 17-alpha-hydroxyprogesterone aldolase|CYPXVII|cytochrome P450 17A1|cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia|cytochrome P450-C17|cytochrome P450c17|cytochrome p450 XVIIA1|steroid 17-alpha-hydroxylase/17,20 lyase|steroid 17-alpha-monooxygenase |
| Swissprots | Q5TZV7 P05093 |
| Accessions | AAA36405 AAA52140 AAA59984 ABF50972 ABF93457 ABY87534 ACT99720 EAW49672 P05093 AI492406 AK094106 AK289898 BAF82587 AK308466 AK312235 BAG35168 BC032843 BC062997 AAH62997 BC063388 AAH63388 BT020000 AAV38803 DA013587 DA016804 M14564 AAA52151 NM_000102 NP_000093 |
| Function | Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. {ECO:0000269|PubMed:22266943}. |
| Subcellular Location | Membrane {ECO:0000305}. |
| Top Pathways | Steroid hormone biosynthesis, Prolactin signaling pathway, Ovarian steroidogenesis |