Gene Symbol | CYP17A1 |
---|---|
Entrez Gene | 1586 |
Alt Symbol | CPT7, CYP17, P450C17, S17AH |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 17, subfamily A, polypeptide 1 |
Other Description | 17-alpha-hydroxyprogesterone aldolase|CYPXVII|cytochrome P450 17A1|cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia|cytochrome P450-C17|cytochrome P450c17|cytochrome p450 XVIIA1|steroid 17-alpha-hydroxylase/17,20 lyase|steroid 17-alpha-monooxygenase |
Swissprots | Q5TZV7 P05093 |
Accessions | AAA36405 AAA52140 AAA59984 ABF50972 ABF93457 ABY87534 ACT99720 EAW49672 P05093 AI492406 AK094106 AK289898 BAF82587 AK308466 AK312235 BAG35168 BC032843 BC062997 AAH62997 BC063388 AAH63388 BT020000 AAV38803 DA013587 DA016804 M14564 AAA52151 NM_000102 NP_000093 |
Function | Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. {ECO:0000269|PubMed:22266943}. |
Subcellular Location | Membrane {ECO:0000305}. |
Top Pathways | Steroid hormone biosynthesis, Prolactin signaling pathway, Ovarian steroidogenesis |
CYP17A1 CRISPR/Cas9 KO Plasmid (h) - sc-401918 from Santa Cruz Biotechnology
|
||||||||
CYP17A1 HDR Plasmid (h) - sc-401918-HDR from Santa Cruz Biotechnology
|
||||||||
CYP17A1 Double Nickase Plasmid (h) - sc-401918-NIC from Santa Cruz Biotechnology
|
||||||||
CYP17A1 Double Nickase Plasmid (h2) - sc-401918-NIC-2 from Santa Cruz Biotechnology
|
||||||||
CYP17A1 CRISPR Activation Plasmid (h) - sc-401918-ACT from Santa Cruz Biotechnology
|
||||||||
CYP17A1 CRISPR Activation Plasmid (h2) - sc-401918-ACT-2 from Santa Cruz Biotechnology
|
||||||||
CYP17A1 Lentiviral Activation Particles (h) - sc-401918-LAC from Santa Cruz Biotechnology
|
||||||||
CYP17A1 Lentiviral Activation Particles (h2) - sc-401918-LAC-2 from Santa Cruz Biotechnology
|
||||||||
CYP17A1 siRNA (h) - sc-45641 from Santa Cruz Biotechnology
|
||||||||
CYP17A1 shRNA Plasmid (h) - sc-45641-SH from Santa Cruz Biotechnology
|
||||||||
CYP17A1 shRNA (h) Lentiviral Particles - sc-45641-V from Santa Cruz Biotechnology
|
||||||||
Cytochrome P450 17A1 RNAi - H00001586-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU120611 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN6873 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6873 from Sigma-Aldrich
|
||||||||
CYP17A1 siRNA (Human) - CRH1115 from Cohesion Biosciences
|
||||||||
CYP17A1 - MBS829911 from MyBioSource
|
||||||||
shRNA set against Human CYP17A1 (NM_000102.3) - SHH272841 from Creative biogene
|
||||||||
shRNA set against Human CYP17A1(NM_000102.3) - SHG215479 from Creative biogene
|
||||||||
CYP17A1 shRNA Plasmid (Human) - CHH1115 from Cohesion Biosciences
|
||||||||
CYP17A1 miRNA 3'UTR clone - MiUTR1H-02609 from Creative biogene
|