| Gene Symbol |
CYP17A1
|
| Entrez Gene |
1586
|
| Alt Symbol |
CPT7, CYP17, P450C17, S17AH
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 17, subfamily A, polypeptide 1
|
| Other Description |
17-alpha-hydroxyprogesterone aldolase|CYPXVII|cytochrome P450 17A1|cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia|cytochrome P450-C17|cytochrome P450c17|cytochrome p450 XVIIA1|steroid 17-alpha-hydroxylase/17,20 lyase|steroid 17-alpha-monooxygenase
|
| Swissprots |
Q5TZV7 P05093
|
| Accessions |
AAA36405 AAA52140 AAA59984 ABF50972 ABF93457 ABY87534 ACT99720 EAW49672 P05093 AI492406 AK094106 AK289898 BAF82587 AK308466 AK312235 BAG35168 BC032843 BC062997 AAH62997 BC063388 AAH63388 BT020000 AAV38803 DA013587 DA016804 M14564 AAA52151 NM_000102 NP_000093
|
| Function |
Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. {ECO:0000269|PubMed:22266943}.
|
| Subcellular Location |
Membrane {ECO:0000305}.
|
| Top Pathways |
Steroid hormone biosynthesis, Prolactin signaling pathway, Ovarian steroidogenesis
|