| Gene Symbol |
DPT
|
| Entrez Gene |
1805
|
| Alt Symbol |
TRAMP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dermatopontin
|
| Other Description |
tyrosine-rich acidic matrix protein
|
| Swissprots |
A8K981 Q07507 Q9UIX8 Q8N4R2
|
| Accessions |
EAW90830 Q07507 AF086330 AI699890 AL049455 BC033736 AAH33736 BP257325 DQ892055 ABM82981 DQ895249 ABM86175 Z22865 CAA80487 NM_001937 NP_001928
|
| Function |
Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000250}.
|
| Tissue Specificity |
Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts. {ECO:0000269|PubMed:10233760, ECO:0000269|PubMed:8104875}.
|
![Western Blot: Dermatopontin Overexpression Lysate (Adult Normal) [NBL1-10005] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Dermatopontin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/19431_Dermatopontin%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-10005-img0002.jpg)