Gene Symbol | DPT |
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Entrez Gene | 1805 |
Alt Symbol | TRAMP |
Species | Human |
Gene Type | protein-coding |
Description | dermatopontin |
Other Description | tyrosine-rich acidic matrix protein |
Swissprots | A8K981 Q07507 Q9UIX8 Q8N4R2 |
Accessions | EAW90830 Q07507 AF086330 AI699890 AL049455 BC033736 AAH33736 BP257325 DQ892055 ABM82981 DQ895249 ABM86175 Z22865 CAA80487 NM_001937 NP_001928 |
Function | Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
Tissue Specificity | Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts. {ECO:0000269|PubMed:10233760, ECO:0000269|PubMed:8104875}. |
Dermatopontin CRISPR/Cas9 KO Plasmid (h) - sc-402924 from Santa Cruz Biotechnology
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Dermatopontin HDR Plasmid (h) - sc-402924-HDR from Santa Cruz Biotechnology
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Dermatopontin Double Nickase Plasmid (h) - sc-402924-NIC from Santa Cruz Biotechnology
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Dermatopontin Double Nickase Plasmid (h2) - sc-402924-NIC-2 from Santa Cruz Biotechnology
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Dermatopontin CRISPR Activation Plasmid (h) - sc-402924-ACT from Santa Cruz Biotechnology
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Dermatopontin CRISPR Activation Plasmid (h2) - sc-402924-ACT-2 from Santa Cruz Biotechnology
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Dermatopontin Lentiviral Activation Particles (h) - sc-402924-LAC from Santa Cruz Biotechnology
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Dermatopontin Lentiviral Activation Particles (h2) - sc-402924-LAC-2 from Santa Cruz Biotechnology
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Dermatopontin siRNA (h) - sc-88148 from Santa Cruz Biotechnology
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Dermatopontin shRNA Plasmid (h) - sc-88148-SH from Santa Cruz Biotechnology
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Dermatopontin shRNA (h) Lentiviral Particles - sc-88148-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU004101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7470 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7470 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07839 from Sigma-Aldrich
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DPT siRNA (Human) - CRH1257 from Cohesion Biosciences
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DPT - MBS8205223 from MyBioSource
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Dermatopontin CRISPR/Cas9 KO Plasmid (h2) - sc-402924-KO-2 from Santa Cruz Biotechnology
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Dermatopontin HDR Plasmid (h2) - sc-402924-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human DPT (NM_001937.4) - SHH280785 from Creative biogene
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DPT shRNA Plasmid (Human) - CHH1257 from Cohesion Biosciences
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DPT miRNA 3'UTR clone - MiUTR3H-00654 from Creative biogene
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