STXBP1

Gene Symbol	STXBP1
Entrez Gene	6812
Alt Symbol	MUNC18-1, NSEC1, P67, RBSEC1, UNC18
Species	Human
Gene Type	protein-coding
Description	syntaxin binding protein 1
Other Description	N-Sec1\|neuronal SEC1\|protein unc-18 homolog 1\|protein unc-18 homolog A\|syntaxin-binding protein 1\|unc-18A\|unc18-1
Swissprots	Q96TG8 Q28208 P61764 Q64320 Q62759 B1AM97
Accessions	EAW87679 EAW87681 P61764 AB209180 BAD92417 AF004562 AAC39688 AF004563 AAC39689 AK094794 AK293984 BAH11641 AK295154 BAH11993 AK295802 BAH12190 BC015749 AAH15749 D63851 BAA19483 DC325017 DQ895426 ABM86352 EU176334 ABW03785 Y12723 CAA73255 NM_001032221 NP_001027392 NM_003165 NP_003156
Function	May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Subcellular Location	Cytoplasm. Membrane; Peripheral membrane protein.
Tissue Specificity	Brain and spinal cord. Highly enriched in axons.
Top Pathways	Synaptic vesicle cycle

Munc18-1 (D4O6V) Rabbit mAb - 13414 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D4O6V

Western blot analysis of extracts from mouse brain, rat brain, and human cortex using Munc18-1 (D4O6V) Rabbit mAb.

Munc18-1 Antibody - 8474 from Cell Signaling Technology

Host	Rabbit
Clonality	Polyclonal

Unc18-1 (31) - sc-136304 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Mouse
Clonality	Monoclonal

Unc18-1 (31): sc-136304. Western blot analysis of Unc18-1 expression in rat cerebrum tissue extract.

Unc18-1 (C-20) - sc-14559 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Unc18-1 (C-20): sc-14559. Western blot analysis of Unc18-1 expression in non-transfected: sc-117752 (A) and mouse Unc18-1 transfected: sc-127749 (B) 293T whole cell lysates.

Unc18-1 (P-17) - sc-14557 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Unc18-1 (P-17): sc-14557. Western blot analysis of Unc18-1 expression in IMR-32 whole cell lysate (A) and mouse brain (B) and rat brain (C) tissue extracts.

Unc18-1/2 (H-300) - sc-33604 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Unc18-1/2 (H-300): sc-33604. Western blot analysis of Unc18-1 expression in non-transfected 293T: sc-117752 (A), mouse Unc18-1 transfected 293T: sc-127749 (B) and IMR-32 (C) whole cell lysates.

Anti-Munc18-1 (phospho S313) antibody - ab138687 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Munc18-1 (phospho S313) antibody (ab138687) at 1/500 dilution + COS7 cell extract, treated with PMA (125ng/ml for 30 mins) at 30 µg

Anti-Munc18-1 (phospho T574) antibody - ab128237 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Munc18-1 antibody - ab52011 from Abcam

Prices	$376.00
Sizes	200 µl
Host	Goat
Clonality	Polyclonal

Anti-Munc18-1 antibody (ab52011) at 0.1 µg/ml + Human Brain lysate (35µg protein in RIPA buffer)

Anti-Munc18-1 antibody - ab57847 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Munc18 antibody (ab57847) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human cerebellum.

Anti-Munc18-1 antibody - ab118901 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry analysis (formalin-fixed, paraffin-embedded) of human brain cortex stained with ab118901 at 10 ug/ml.

Anti-Munc18-1 antibody [6D1] - ab117632 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	6D1

ab117632, at 5 µg/ml, staining Munc18 in Formalin-fixed, Paraffin-embedded Human Brain (Neuropil) tissue by Immunohistochemistry.

Anti-Munc18-1 antibody [EPR4849] - ab109023 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR4849

All lanes : Anti-Munc18-1 antibody [EPR4849] (ab109023) at 1/1000 dilutionLane 1 : SH SY5Y cell lysateLane 2 : Human fetal brain lysateLysates/proteins at 10 µg per lane.

Anti-Munc18-1 antibody [EPR4850] - ab124920 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR4850

All lanes : Anti-Munc18-1 antibody [EPR4850] (ab124920) at 1/10000 dilutionLane 1 : SH-SY5Y cell lysateLane 2 : HeLa cell lysateLane 3 : Jurkat cell lysateLane 4 : Y79 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-STXBP1 / MUNC18-1 Antibody (phospho-Ser313) - LS-C199288 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts from COS7 cells treated with PMA 125ng/ml 30', using MUNC-18a (Phospho-Ser313) Antibody. The lane on the right was incubated with synthetic peptide.

Anti-STXBP1 / MUNC18-1 Antibody (aa279-328) IHC-plus™ - LS-B5576 from LifeSpan Bioscience

Prices	$395.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-STXBP1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5576 concentration 10 ug/ml.

Anti-STXBP1 / MUNC18-1 Antibody (Internal, clone EPR4850) - LS-C138310 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR4850

IHC of paraffin-embedded human brain tissue using anti-STXBP1antibody.

Anti-STXBP1 / MUNC18-1 Antibody (Internal, clone EPR4849) - LS-C138404 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR4849

Immunofluorescent staining of SH-SY5Y cells using anti-STXBP1 antibody

Anti-STXBP1 / MUNC18-1 Antibody - LS-C335568 from LifeSpan Bioscience

Prices	$255.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of paraffin-embedded human esophageal cancer using STXBP1 antibody at dilution of 1:200 (x400 lens).

Anti-STXBP1 / MUNC18-1 Antibody (clone 6D1) IHC-plus™ - LS-B5542 from LifeSpan Bioscience

Prices	$450.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	6D1

Anti-STXBP1 antibody IHC of human brain, neuropil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5542 concentration 5 ug/ml.

Anti-STXBP1 / MUNC18-1 Antibody (C-Terminus) IHC-plus™ - LS-B4446 from LifeSpan Bioscience

Prices	$395.00
Sizes	50 µg
Host	Goat
Clonality	Polyclonal

Anti-STXBP1 / MUNC18-1 Antibody (phospho-Ser515) - LS-C72050 from LifeSpan Bioscience

Prices	$485.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-STXBP1 / MUNC18-1 Antibody (Internal) - LS-C94840 from LifeSpan Bioscience

Prices	$325.00
Sizes	500 µg
Host	Rabbit
Clonality	Polyclonal

Anti-STXBP1 / MUNC18-1 Antibody (aa504-553) - LS-C102845 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-STXBP1 / MUNC18-1 Antibody (aa1-603) - LS-C132345 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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