| Gene Symbol |
STXBP1
|
| Entrez Gene |
6812
|
| Alt Symbol |
MUNC18-1, NSEC1, P67, RBSEC1, UNC18
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
syntaxin binding protein 1
|
| Other Description |
N-Sec1|neuronal SEC1|protein unc-18 homolog 1|protein unc-18 homolog A|syntaxin-binding protein 1|unc-18A|unc18-1
|
| Swissprots |
Q96TG8 Q28208 P61764 Q64320 Q62759 B1AM97
|
| Accessions |
EAW87679 EAW87681 P61764 AB209180 BAD92417 AF004562 AAC39688 AF004563 AAC39689 AK094794 AK293984 BAH11641 AK295154 BAH11993 AK295802 BAH12190 BC015749 AAH15749 D63851 BAA19483 DC325017 DQ895426 ABM86352 EU176334 ABW03785 Y12723 CAA73255 NM_001032221 NP_001027392 NM_003165 NP_003156
|
| Function |
May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
|
| Subcellular Location |
Cytoplasm. Membrane; Peripheral membrane protein.
|
| Tissue Specificity |
Brain and spinal cord. Highly enriched in axons.
|
| Top Pathways |
Synaptic vesicle cycle
|
