| Gene Symbol | C9orf142 |
|---|---|
| Entrez Gene | 286257 |
| Alt Symbol | PAXX |
| Species | Human |
| Gene Type | protein-coding |
| Description | chromosome 9 open reading frame 142 |
| Other Description | paralog of XRCC4 and XLF|protein PAXX |
| Swissprots | Q9BUH6 Q8IY19 |
| Accessions | EAW88324 EAW88325 EAW88326 EAW88327 EAW88328 Q9BUH6 BC002613 AAH02613 BC038191 AAH38191 HQ447605 ADQ32091 NM_183241 NP_899064 |
| Function | Involved in DNA non-homologous end joining (NHEJ). May act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at DNA ends and thus promote assembly and/or stability of the NHEJ machinery at double- strand break (DSB) sites. {ECO:0000269|PubMed:25574025}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:25574025}. Note=Predominantly localizes to the nucleus. Accumulates at sites of DNA damage generated by laser microirradiation. {ECO:0000269|PubMed:25574025}. |
chromosome 9 open reading frame 142, ELISA Kit - MBS9325002 from MyBioSource
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Human C9orf142 ELISA Kit - E009351 from Biobool
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