Gene Symbol | C9orf142 |
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Entrez Gene | 286257 |
Alt Symbol | PAXX |
Species | Human |
Gene Type | protein-coding |
Description | chromosome 9 open reading frame 142 |
Other Description | paralog of XRCC4 and XLF|protein PAXX |
Swissprots | Q9BUH6 Q8IY19 |
Accessions | EAW88324 EAW88325 EAW88326 EAW88327 EAW88328 Q9BUH6 BC002613 AAH02613 BC038191 AAH38191 HQ447605 ADQ32091 NM_183241 NP_899064 |
Function | Involved in DNA non-homologous end joining (NHEJ). May act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at DNA ends and thus promote assembly and/or stability of the NHEJ machinery at double- strand break (DSB) sites. {ECO:0000269|PubMed:25574025}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:25574025}. Note=Predominantly localizes to the nucleus. Accumulates at sites of DNA damage generated by laser microirradiation. {ECO:0000269|PubMed:25574025}. |
C9orf142 CRISPR/Cas9 KO Plasmid (h) - sc-406152 from Santa Cruz Biotechnology
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C9orf142 HDR Plasmid (h) - sc-406152-HDR from Santa Cruz Biotechnology
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C9orf142 Double Nickase Plasmid (h) - sc-406152-NIC from Santa Cruz Biotechnology
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C9orf142 Double Nickase Plasmid (h2) - sc-406152-NIC-2 from Santa Cruz Biotechnology
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C9orf142 CRISPR Activation Plasmid (h) - sc-406152-ACT from Santa Cruz Biotechnology
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C9orf142 CRISPR Activation Plasmid (h2) - sc-406152-ACT-2 from Santa Cruz Biotechnology
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C9orf142 Lentiviral Activation Particles (h) - sc-406152-LAC from Santa Cruz Biotechnology
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C9orf142 Lentiviral Activation Particles (h2) - sc-406152-LAC-2 from Santa Cruz Biotechnology
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C9orf142 siRNA (h) - sc-92704 from Santa Cruz Biotechnology
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C9orf142 shRNA Plasmid (h) - sc-92704-SH from Santa Cruz Biotechnology
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C9orf142 shRNA (h) Lentiviral Particles - sc-92704-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU027071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5180 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5180 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00482 from Sigma-Aldrich
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C9orf142 siRNA (Human) - CRJ7163 from Cohesion Biosciences
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C9orf142 - MBS8209277 from MyBioSource
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shRNA set against Human C9orf142 (NM_183241.1) - SHH252837 from Creative biogene
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Human C9orf142 siRNA - orb277664 from Biorbyt
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C9orf142 shRNA Plasmid (Human) - CHJ7163 from Cohesion Biosciences
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C9ORF142 miRNA 3'UTR clone - MiUTR1H-01518 from Creative biogene
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