| Gene Symbol |
C9orf142
|
| Entrez Gene |
286257
|
| Alt Symbol |
PAXX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chromosome 9 open reading frame 142
|
| Other Description |
paralog of XRCC4 and XLF|protein PAXX
|
| Swissprots |
Q9BUH6 Q8IY19
|
| Accessions |
EAW88324 EAW88325 EAW88326 EAW88327 EAW88328 Q9BUH6 BC002613 AAH02613 BC038191 AAH38191 HQ447605 ADQ32091 NM_183241 NP_899064
|
| Function |
Involved in DNA non-homologous end joining (NHEJ). May act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at DNA ends and thus promote assembly and/or stability of the NHEJ machinery at double- strand break (DSB) sites. {ECO:0000269|PubMed:25574025}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:25574025}. Note=Predominantly localizes to the nucleus. Accumulates at sites of DNA damage generated by laser microirradiation. {ECO:0000269|PubMed:25574025}.
|
