| Gene Symbol |
H1FNT
|
| Entrez Gene |
341567
|
| Alt Symbol |
H1.7, H1T2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
H1 histone family, member N, testis-specific
|
| Other Description |
HANP1|haploid germ cell-specific nuclear protein 1|histone H1t2|testis-specific H1 histone
|
| Swissprots |
Q147U8 Q75WM6 Q7Z694 Q5GKZ5
|
| Accessions |
AAS49492 Q75WM6 AB121028 BAD13382 AY302593 AAP60022 BC118635 AAI18636 BC119787 AAI19788 NM_181788 NP_861453
|
| Function |
Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone- protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole. {ECO:0000250}.
|
| Tissue Specificity |
Testis-specific. {ECO:0000269|PubMed:16533358}.
|