Gene Symbol | H1FNT |
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Entrez Gene | 341567 |
Alt Symbol | H1.7, H1T2 |
Species | Human |
Gene Type | protein-coding |
Description | H1 histone family, member N, testis-specific |
Other Description | HANP1|haploid germ cell-specific nuclear protein 1|histone H1t2|testis-specific H1 histone |
Swissprots | Q147U8 Q75WM6 Q7Z694 Q5GKZ5 |
Accessions | AAS49492 Q75WM6 AB121028 BAD13382 AY302593 AAP60022 BC118635 AAI18636 BC119787 AAI19788 NM_181788 NP_861453 |
Function | Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone- protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1 (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole. {ECO:0000250}. |
Tissue Specificity | Testis-specific. {ECO:0000269|PubMed:16533358}. |
H1T2 CRISPR/Cas9 KO Plasmid (h) - sc-415568 from Santa Cruz Biotechnology
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H1T2 HDR Plasmid (h) - sc-415568-HDR from Santa Cruz Biotechnology
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H1T2 Double Nickase Plasmid (h) - sc-415568-NIC from Santa Cruz Biotechnology
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H1T2 Double Nickase Plasmid (h2) - sc-415568-NIC-2 from Santa Cruz Biotechnology
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H1T2 CRISPR Activation Plasmid (h) - sc-415568-ACT from Santa Cruz Biotechnology
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H1T2 CRISPR Activation Plasmid (h2) - sc-415568-ACT-2 from Santa Cruz Biotechnology
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H1T2 Lentiviral Activation Particles (h) - sc-415568-LAC from Santa Cruz Biotechnology
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H1T2 Lentiviral Activation Particles (h2) - sc-415568-LAC-2 from Santa Cruz Biotechnology
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H1T2 siRNA (h) - sc-95952 from Santa Cruz Biotechnology
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H1T2 shRNA Plasmid (h) - sc-95952-SH from Santa Cruz Biotechnology
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H1T2 shRNA (h) Lentiviral Particles - sc-95952-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU136491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9833 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9833 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00876 from Sigma-Aldrich
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H1FNT siRNA (Human) - CRJ7382 from Cohesion Biosciences
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H1FNT - MBS8200963 from MyBioSource
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shRNA set against Human H1fnt (NM_181788.1) - SHH309750 from Creative biogene
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H1FNT shRNA Plasmid (Human) - CHJ7382 from Cohesion Biosciences
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H1FNT miRNA 3'UTR clone - MiUTR1H-04345 from Creative biogene
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