Crtc2

Gene Symbol	Crtc2
Entrez Gene	310615
Alt Symbol	RGD1308903, Torc2
Species	Rat
Gene Type	protein-coding
Description	CREB regulated transcription coactivator 2
Other Description	CREB-regulated transcription coactivator 2\|TORC-2\|transducer of CREB protein 2\|transducer of regulated cAMP response element-binding protein 2
Swissprots	Q3LRZ1
Accessions	EDM00574 Q3LRZ1 BC128708 BC168242 AAI68242 DQ185515 ABA28301 XM_008761146 XP_008759368 XR_591181 NM_001033895 NP_001029067
Function	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus (By similarity). {ECO:0000250}.
Top Pathways	HTLV-I infection, PI3K-Akt signaling pathway, AMPK signaling pathway, Glucagon signaling pathway

Host	Rabbit

Prices	$240.00, $295.00, $415.00, $540.00, $540.00
Sizes	100 µl peptide, 0.1-0.15 ml wb control, 200 µl affinity purified, 200 µl biotin, 200 µl fitc
Host	Rabbit
Clonality	Polyclonal

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