Crtc2

Gene Symbol Crtc2
Entrez Gene 310615
Alt Symbol RGD1308903, Torc2
Species Rat
Gene Type protein-coding
Description CREB regulated transcription coactivator 2
Other Description CREB-regulated transcription coactivator 2|TORC-2|transducer of CREB protein 2|transducer of regulated cAMP response element-binding protein 2
Swissprots Q3LRZ1
Accessions EDM00574 Q3LRZ1 BC128708 BC168242 AAI68242 DQ185515 ABA28301 XM_008761146 XP_008759368 XR_591181 NM_001033895 NP_001029067
Function Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus (By similarity). {ECO:0000250}.
Top Pathways HTLV-I infection, PI3K-Akt signaling pathway, AMPK signaling pathway, Glucagon signaling pathway

CompoZr® Knockout ZFN Kit - CKOZFN52481 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND52481 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CRTC2 siRNA (Rat) - CRR5262 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

CRTC2 - MBS8238612 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

shRNA set against Rat CRTC2 (NM_001033895.1) - SHH269837 from Creative biogene

Category siRNA
Species Reactivities Rat

shRNA set against Rat Crtc2(NM_001033895.1) - SHG200503 from Creative biogene

Category siRNA
Species Reactivities Rat

Rat CRTC2 siRNA - orb300111 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

CRTC2 shRNA Plasmid (Rat) - CHR5262 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Rat

CRTC2 miRNA 3'UTR clone - MiUTR1R-01193 from Creative biogene

Species Reactivities Rat
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