| Gene Symbol | Crtc2 |
|---|---|
| Entrez Gene | 310615 |
| Alt Symbol | RGD1308903, Torc2 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | CREB regulated transcription coactivator 2 |
| Other Description | CREB-regulated transcription coactivator 2|TORC-2|transducer of CREB protein 2|transducer of regulated cAMP response element-binding protein 2 |
| Swissprots | Q3LRZ1 |
| Accessions | EDM00574 Q3LRZ1 BC128708 BC168242 AAI68242 DQ185515 ABA28301 XM_008761146 XP_008759368 XR_591181 NM_001033895 NP_001029067 |
| Function | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus (By similarity). {ECO:0000250}. |
| Top Pathways | HTLV-I infection, PI3K-Akt signaling pathway, AMPK signaling pathway, Glucagon signaling pathway |
Recombinant Rat CREB-regulated transcription coactivator 2(Crtc2) - CSB-YP667310RA CSB-EP667310RA CSB-BP667310RA CSB-MP667310RA from Cusabio
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TORC2, Peptide - MBS843727 from MyBioSource
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CREB-regulated transcription coactivator 2 (Crtc2), Recombinant Protein - MBS1361347 from MyBioSource
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