| Gene Symbol |
Crtc2
|
| Entrez Gene |
310615
|
| Alt Symbol |
RGD1308903, Torc2
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
CREB regulated transcription coactivator 2
|
| Other Description |
CREB-regulated transcription coactivator 2|TORC-2|transducer of CREB protein 2|transducer of regulated cAMP response element-binding protein 2
|
| Swissprots |
Q3LRZ1
|
| Accessions |
EDM00574 Q3LRZ1 BC128708 BC168242 AAI68242 DQ185515 ABA28301 XM_008761146 XP_008759368 XR_591181 NM_001033895 NP_001029067
|
| Function |
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus (By similarity). {ECO:0000250}.
|
| Top Pathways |
HTLV-I infection, PI3K-Akt signaling pathway, AMPK signaling pathway, Glucagon signaling pathway
|