Gene Symbol | TNFSF15 |
---|---|
Entrez Gene | 9966 |
Alt Symbol | TL1, TL1A, VEGI, VEGI192A |
Species | Human |
Gene Type | protein-coding |
Description | tumor necrosis factor (ligand) superfamily, member 15 |
Other Description | TNF ligand-related molecule 1|TNF superfamily ligand TL1A|tumor necrosis factor ligand superfamily member 15|vascular endothelial cell growth inhibitor|vascular endothelial growth inhibitor-192A |
Swissprots | Q5VWH1 Q8NFE9 O95150 Q3SX69 Q5VJK8 |
Accessions | BAJ13472 BAJ13473 CAV13212 EAW87431 O95150 AF039390 AAD08783 AF520785 AAM77366 AK291642 BAF84331 AK313721 AW014795 AY434464 AAR98573 BC069435 AAH69435 BC074940 AAH74940 BC074941 AAH74941 BC104462 AAI04463 BC104463 AAI04464 NM_001204344 NP_001191273 NM_005118 NP_005109 |
Function | Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. {ECO:0000269|PubMed:10597252, ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:9872942}. |
Subcellular Location | Membrane {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}; Single-pass type II membrane protein {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}. |
Tissue Specificity | Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. {ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:9434163, ECO:0000269|PubMed:9872942}. |
Top Pathways | Cytokine-cytokine receptor interaction |
VEGI (P-18) - sc-23186 from Santa Cruz Biotechnology
|
||||||||||
VEGI (Q-20) - sc-13627 from Santa Cruz Biotechnology
|
||||||||||
VEGI (F-15) - sc-23185 from Santa Cruz Biotechnology
|
||||||||||
VEGI (FL-174) - sc-32945 from Santa Cruz Biotechnology
|
||||||||||
VEGI (1A3) - sc-53975 from Santa Cruz Biotechnology
|
||||||||||
Anti-TL1A antibody - ab85566 from Abcam
|
||||||||||
Anti-TL1A antibody - ab21272 from Abcam
|
||||||||||
Anti-TL1A antibody - ab64986 from Abcam
|
||||||||||
Anti-TL1A antibody - ab37169 from Abcam
|
||||||||||
Anti-TL1A antibody - ab169357 from Abcam
|
||||||||||
Anti-TL1A antibody - ab109829 from Abcam
|
||||||||||
Anti-TL1A antibody (Biotin) - ab84233 from Abcam
|
||||||||||
Anti-TNFSF15 / TL1A / VEGI Antibody (C-Terminus) - LS-C18487 from LifeSpan Bioscience
|
||||||||||
Anti-TNFSF15 / TL1A / VEGI Antibody - LS-C18625 from LifeSpan Bioscience
|
||||||||||
Anti-TNFSF15 / TL1A / VEGI Antibody (clone L4G9) - LS-C18722 from LifeSpan Bioscience
|
||||||||||
Anti-TNFSF15 / TL1A / VEGI Antibody (Biotin) - LS-C104288 from LifeSpan Bioscience
|
||||||||||
Anti-TNFSF15 / TL1A / VEGI Antibody (aa155-183, PE) - LS-C241951 from LifeSpan Bioscience
|
||||||||||
Anti-TNFSF15 / TL1A / VEGI Antibody (aa155-183, FITC) - LS-C241950 from LifeSpan Bioscience
|
||||||||||
Anti-TNFSF15 / TL1A / VEGI Antibody (aa155-183, AP) - LS-C241947 from LifeSpan Bioscience
|
||||||||||
Anti-TNFSF15 / TL1A / VEGI Antibody (aa155-183, APC) - LS-C241948 from LifeSpan Bioscience
|
||||||||||
Anti-TNFSF15 / TL1A / VEGI Antibody (aa155-183, Azide-free, HRP) - LS-C247097 from LifeSpan Bioscience
|
||||||||||
Anti-TNFSF15 / TL1A / VEGI Antibody - LS-C19591 from LifeSpan Bioscience
|
||||||||||
Anti-TNFSF15 / TL1A / VEGI Antibody (aa155-183) - LS-C330242 from LifeSpan Bioscience
|
||||||||||
Anti-TNFSF15 / TL1A / VEGI Antibody (clone Tingo-1) - LS-C343740 from LifeSpan Bioscience
|
||||||||||
Anti-TNFSF15 / TL1A / VEGI Antibody - LS-C343714 from LifeSpan Bioscience
|