Gene Symbol | TNFSF15 |
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Entrez Gene | 9966 |
Alt Symbol | TL1, TL1A, VEGI, VEGI192A |
Species | Human |
Gene Type | protein-coding |
Description | tumor necrosis factor (ligand) superfamily, member 15 |
Other Description | TNF ligand-related molecule 1|TNF superfamily ligand TL1A|tumor necrosis factor ligand superfamily member 15|vascular endothelial cell growth inhibitor|vascular endothelial growth inhibitor-192A |
Swissprots | Q5VWH1 Q8NFE9 O95150 Q3SX69 Q5VJK8 |
Accessions | BAJ13472 BAJ13473 CAV13212 EAW87431 O95150 AF039390 AAD08783 AF520785 AAM77366 AK291642 BAF84331 AK313721 AW014795 AY434464 AAR98573 BC069435 AAH69435 BC074940 AAH74940 BC074941 AAH74941 BC104462 AAI04463 BC104463 AAI04464 NM_001204344 NP_001191273 NM_005118 NP_005109 |
Function | Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. {ECO:0000269|PubMed:10597252, ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:9872942}. |
Subcellular Location | Membrane {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}; Single-pass type II membrane protein {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}. |
Tissue Specificity | Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. {ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:9434163, ECO:0000269|PubMed:9872942}. |
Top Pathways | Cytokine-cytokine receptor interaction |
Chicken TL1A protein fragment - ab90800 from Abcam
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Human TL1A full length protein - ab107131 from Abcam
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Human TL1A peptide - ab41854 from Abcam
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Human TL1A protein fragment - ab157061 from Abcam
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Human TL1A protein fragment - ab50094 from Abcam
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Human TL1A protein fragment - ab169880 from Abcam
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Human TL1A protein fragment - ab182833 from Abcam
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Mouse TL1A protein fragment - ab157011 from Abcam
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TNFSF15 / TL1A / VEGI Antibody Blocking Peptide - LS-E1284 from LifeSpan Bioscience
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TNFSF15 / TL1A / VEGI Antibody Blocking Peptide - LS-E30012 from LifeSpan Bioscience
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Recombinant Human TL1A/TNFSF15 Protein - NBP2-35067 from Novus Biologicals
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TL1A/TNFSF15 Recombinant Protein - H00009966-P01 from Novus Biologicals
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TL1A/TNFSF15 Partial Recombinant Protein - H00009966-Q01 from Novus Biologicals
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TL1A/TNFSF15 Blocking Peptide - NBP1-76450PEP from Novus Biologicals
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Recombinant Human TL1A/TNFSF15 Protein - NBP1-99602 from Novus Biologicals
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TL1A/TNFSF15 Protein - NBP1-99776 from Novus Biologicals
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Recombinant Human TL1A/TNFSF15 Protein - NBP1-72297 from Novus Biologicals
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TNFSF15-Antibody-Center-Blocking-peptide - BP11879c from Abgent, a WuXi AppTec company
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TL1A Recombinant Protein (Active) - GTX48085-PRO from GeneTex
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TL1A (Active) recombinant protein - GTX65483 from GeneTex
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TL1A (Active) recombinant protein - GTX65482 from GeneTex
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Recombinant Human TL1A/TNFSF15 - 1319-TL-010 from R&D Systems
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Recombinant Human TL1A/TNFSF15, CF - 1319-TL-010/CF from R&D Systems
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Human VEGI protein - orb180577 from Biorbyt
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Human Vascular Endothelial Growth Inhibitor protein - orb80647 from Biorbyt
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