Gene Symbol | TNFSF15 |
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Entrez Gene | 9966 |
Alt Symbol | TL1, TL1A, VEGI, VEGI192A |
Species | Human |
Gene Type | protein-coding |
Description | tumor necrosis factor (ligand) superfamily, member 15 |
Other Description | TNF ligand-related molecule 1|TNF superfamily ligand TL1A|tumor necrosis factor ligand superfamily member 15|vascular endothelial cell growth inhibitor|vascular endothelial growth inhibitor-192A |
Swissprots | Q5VWH1 Q8NFE9 O95150 Q3SX69 Q5VJK8 |
Accessions | BAJ13472 BAJ13473 CAV13212 EAW87431 O95150 AF039390 AAD08783 AF520785 AAM77366 AK291642 BAF84331 AK313721 AW014795 AY434464 AAR98573 BC069435 AAH69435 BC074940 AAH74940 BC074941 AAH74941 BC104462 AAI04463 BC104463 AAI04464 NM_001204344 NP_001191273 NM_005118 NP_005109 |
Function | Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. {ECO:0000269|PubMed:10597252, ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:9872942}. |
Subcellular Location | Membrane {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}; Single-pass type II membrane protein {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}. |
Tissue Specificity | Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. {ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:9434163, ECO:0000269|PubMed:9872942}. |
Top Pathways | Cytokine-cytokine receptor interaction |
VEGI CRISPR/Cas9 KO Plasmid (h) - sc-404609 from Santa Cruz Biotechnology
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VEGI HDR Plasmid (h) - sc-404609-HDR from Santa Cruz Biotechnology
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VEGI Double Nickase Plasmid (h) - sc-404609-NIC from Santa Cruz Biotechnology
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VEGI Double Nickase Plasmid (h2) - sc-404609-NIC-2 from Santa Cruz Biotechnology
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VEGI CRISPR Activation Plasmid (h) - sc-404609-ACT from Santa Cruz Biotechnology
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VEGI CRISPR Activation Plasmid (h2) - sc-404609-ACT-2 from Santa Cruz Biotechnology
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VEGI Lentiviral Activation Particles (h) - sc-404609-LAC from Santa Cruz Biotechnology
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VEGI Lentiviral Activation Particles (h2) - sc-404609-LAC-2 from Santa Cruz Biotechnology
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VEGI siRNA (h) - sc-39846 from Santa Cruz Biotechnology
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VEGI shRNA Plasmid (h) - sc-39846-SH from Santa Cruz Biotechnology
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VEGI shRNA (h) Lentiviral Particles - sc-39846-V from Santa Cruz Biotechnology
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TL1A/TNFSF15 RNAi - H00009966-R01 from Novus Biologicals
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MISSION® esiRNA - EHU012601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21766 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21766 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08640 from Sigma-Aldrich
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TNFSF15 siRNA (Human) - CRH6703 from Cohesion Biosciences
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TNFSF15 - MBS8207464 from MyBioSource
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shRNA set against Human TNFSF15 (NM_005118.3) - SHH432160 from Creative biogene
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Human TNFSF15 siRNA - orb267205 from Biorbyt
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TNFSF15 shRNA Plasmid (Human) - CHH6703 from Cohesion Biosciences
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TNFSF15 miRNA 3'UTR clone - MiUTR3H-06472 from Creative biogene
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