| Gene Symbol | TNFSF15 |
|---|---|
| Entrez Gene | 9966 |
| Alt Symbol | TL1, TL1A, VEGI, VEGI192A |
| Species | Human |
| Gene Type | protein-coding |
| Description | tumor necrosis factor (ligand) superfamily, member 15 |
| Other Description | TNF ligand-related molecule 1|TNF superfamily ligand TL1A|tumor necrosis factor ligand superfamily member 15|vascular endothelial cell growth inhibitor|vascular endothelial growth inhibitor-192A |
| Swissprots | Q5VWH1 Q8NFE9 O95150 Q3SX69 Q5VJK8 |
| Accessions | BAJ13472 BAJ13473 CAV13212 EAW87431 O95150 AF039390 AAD08783 AF520785 AAM77366 AK291642 BAF84331 AK313721 AW014795 AY434464 AAR98573 BC069435 AAH69435 BC074940 AAH74940 BC074941 AAH74941 BC104462 AAI04463 BC104463 AAI04464 NM_001204344 NP_001191273 NM_005118 NP_005109 |
| Function | Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. {ECO:0000269|PubMed:10597252, ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:9872942}. |
| Subcellular Location | Membrane {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}; Single-pass type II membrane protein {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}. |
| Tissue Specificity | Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. {ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:9434163, ECO:0000269|PubMed:9872942}. |
| Top Pathways | Cytokine-cytokine receptor interaction |