| Gene Symbol | Faslg |
|---|---|
| Entrez Gene | 25385 |
| Alt Symbol | Apt1Lg1, CD95-L, Fasl, Tnfsf6 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | Fas ligand (TNF superfamily, member 6) |
| Other Description | Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand)|CD95 ligand|CD95L protein|Fas antigen ligand|Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)|Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)|tumor necrosis factor ligand superfamily member 6 |
| Swissprots | P36940 |
| Accessions | EDM09413 P36940 AF104035 U03470 AAC52129 XM_006250148 XP_006250210 XM_008769607 XP_008767829 NM_012908 NP_037040 |
| Function | Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects (By similarity). {ECO:0000250}. |
| Subcellular Location | FasL intracellular domain: Nucleus {ECO:0000250}. Note=The FasL ICD cytoplasmic form is translocated into the nucleus. {ECO:0000250}. |
| Tissue Specificity | Expressed in activated splenocytes and thymocytes. Moderate or weak expression found in small intestines, kidney and lung. |
| Top Pathways | Chagas disease (American trypanosomiasis), PI3K-Akt signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Herpes simplex infection, Proteoglycans in cancer |