| Gene Symbol |
Faslg
|
| Entrez Gene |
25385
|
| Alt Symbol |
Apt1Lg1, CD95-L, Fasl, Tnfsf6
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
Fas ligand (TNF superfamily, member 6)
|
| Other Description |
Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand)|CD95 ligand|CD95L protein|Fas antigen ligand|Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)|Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)|tumor necrosis factor ligand superfamily member 6
|
| Swissprots |
P36940
|
| Accessions |
EDM09413 P36940 AF104035 U03470 AAC52129 XM_006250148 XP_006250210 XM_008769607 XP_008767829 NM_012908 NP_037040
|
| Function |
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects (By similarity). {ECO:0000250}.
|
| Subcellular Location |
FasL intracellular domain: Nucleus {ECO:0000250}. Note=The FasL ICD cytoplasmic form is translocated into the nucleus. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in activated splenocytes and thymocytes. Moderate or weak expression found in small intestines, kidney and lung.
|
| Top Pathways |
Chagas disease (American trypanosomiasis), PI3K-Akt signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Herpes simplex infection, Proteoglycans in cancer
|