| Gene Symbol |
PDE5A
|
| Entrez Gene |
8654
|
| Alt Symbol |
CGB-PDE, CN5A, PDE5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphodiesterase 5A, cGMP-specific
|
| Other Description |
cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase|cGMP-specific 3',5'-cyclic phosphodiesterase|cGMP-specific phosphodiesterase PDE5A2|cGMP-specific phosphodiesterase type 5A|phosphodiesterase isozyme 5
|
| Swissprots |
Q86UI0 O75887 O75026 A0AV69 Q86V66 O76074 Q9Y6Z6 A8K2C4
|
| Accessions |
AAF40301 AAF40302 AAK08016 AAY40985 BAA33372 EAX05275 EAX05276 EAX05277 EAX05278 O76074 AB015656 BAA81667 AF043731 AAC63967 AF043732 AAC63968 AF155192 AAF40303 AF155193 AAF40304 AF155194 AAF40305 AJ004865 CAA06170 AK290189 BAF82878 AM392687 CAL37565 AM392735 CAL37613 AM392945 CAL37823 AM393036 CAL37914 AM393171 CAL38049 AM393270 CAL38148 AM393311 CAL38189 AM393426 CAL38304 AM393432 CAL38310 AM393448 CAL38326 AM393814 CAL38689 AY264918 AAP21809 AY266363 AAP31235 BC126233 AAI26234 BM920622 BM978332 CD511199 JQ286346 AEW91484 NM_001083 NP_001074 NM_033430 NP_236914 NM_033437 NP_246273
|
| Function |
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP.
|
| Tissue Specificity |
Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.
|
| Top Pathways |
cGMP-PKG signaling pathway, Purine metabolism
|
![Western Blot: PDE5A Overexpression Lysate (Adult Normal) [NBL1-14225] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PDE5A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1094_PDE5A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14225-img0002.jpg)