PDE5A

Gene Symbol PDE5A
Entrez Gene 8654
Alt Symbol CGB-PDE, CN5A, PDE5
Species Human
Gene Type protein-coding
Description phosphodiesterase 5A, cGMP-specific
Other Description cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase|cGMP-specific 3',5'-cyclic phosphodiesterase|cGMP-specific phosphodiesterase PDE5A2|cGMP-specific phosphodiesterase type 5A|phosphodiesterase isozyme 5
Swissprots Q86UI0 O75887 O75026 A0AV69 Q86V66 O76074 Q9Y6Z6 A8K2C4
Accessions AAF40301 AAF40302 AAK08016 AAY40985 BAA33372 EAX05275 EAX05276 EAX05277 EAX05278 O76074 AB015656 BAA81667 AF043731 AAC63967 AF043732 AAC63968 AF155192 AAF40303 AF155193 AAF40304 AF155194 AAF40305 AJ004865 CAA06170 AK290189 BAF82878 AM392687 CAL37565 AM392735 CAL37613 AM392945 CAL37823 AM393036 CAL37914 AM393171 CAL38049 AM393270 CAL38148 AM393311 CAL38189 AM393426 CAL38304 AM393432 CAL38310 AM393448 CAL38326 AM393814 CAL38689 AY264918 AAP21809 AY266363 AAP31235 BC126233 AAI26234 BM920622 BM978332 CD511199 JQ286346 AEW91484 NM_001083 NP_001074 NM_033430 NP_236914 NM_033437 NP_246273
Function Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP.
Tissue Specificity Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.
Top Pathways cGMP-PKG signaling pathway, Purine metabolism

PDE5 (P434) Antibody - 3585 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from LN-18 cells using PDE5 (P434) Antibody.

PDE5 Antibody - 2395 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extract from LN-18 cells, using PDE5 Antibody.

PDE5 Antibody - 4072 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

PDE5A (D-3) - sc-398747 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PDE5A (D-3): sc-398747. Western blot analysis of PDE5A expression in HEK293 whole cell lysate.

PDE5A (H-120) - sc-32884 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PDE5A (H-120): sc-32884. Western blot analysis of PDE5A expression in non-transfected: sc-110760 (A) and human PDE5A transfected: sc-129427 (B) 293 whole cell lysates.

PDE5A (K-20) - sc-30459 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PDE5A (N-18) - sc-30458 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PDE5A antibody - ab14672 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab14672 (4µg/ml) staining PDE5A in human oesophagus using an automated system (DAKO Autostainer Plus). Using this protocol there is staining of the cytoplasm and nuclei in stratified squamous epithelium cells.Sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffers EDTA pH 9.0 in a DAKO PT link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako envision flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that, for manual staining, optimization of primary antibody concentration and incubation time is recommended. Signal amplification may be required.

Anti-PDE5A antibody - ab56505 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56505 PDE5A antibody at 1ug/ml.

PDE5A Antibody - NBP1-86139 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: PDE5A Antibody [NBP1-86139] - Staining of human duodenum shows moderate cytoplasmic positivity in glandular cells.

PDE5A Antibody - NBP1-00639 from Novus Biologicals

Prices $469.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PDE5A Antibody [NBP1-00639] - Western blot using PDE5A1 antibody (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform.

PDE5A Antibody - NB300-655 from Novus Biologicals

Prices $449.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PDE5A Antibody [NB300-655] - 50 ug of rat lung Homogentate.

PDE5A Antibody - NBP1-86469 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: PDE5A Antibody [NBP1-86469] - Staining of human duodenum shows strong membranous and cytoplasmic positivity in glandular cells.

PDE5A Antibody - NB300-957 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: PDE5A Antibody [NB300-957] - HEK293 overexpressing PDE5A and probed with (mock transfection in first lane).

PDE5A Antibody (9H5) - H00008654-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 9H5

PDE5A Antibody - NB110-40466 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

PDE5A Antibody - H00008654-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

PDE5A Polyclonal Antibody - bs-2349R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human cervical carcinoma labeled with Anti-PDE5A Polyclonal Antibody, Unconjugated(bs-2349R) at 1:200 followed by conjugation to the secondary antibody

Anti-PDE5A antibody produced in rabbit - HPA012873 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PDE5A: <B>Cat. No. HPA012873</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human duodenum shows strong membranous and cytoplasmic positivity in glandular cells.

Anti-PDE5A antibody produced in goat - SAB2500767 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PDE5A: <B>Cat. No. SAB2500767</B>: staining (0.3 μg/mL) of human lung lysate (RIPA buffer, 30 μg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Anti-PDE5A antibody produced in rabbit - HPA004729 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PDE5A: <B>Cat. No. HPA004729</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human pancreatic tissue showing cytoplasmic staining of islet cells and of cells in ducts.

Monoclonal Anti-PDE5A antibody produced in mouse - WH0008654M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 9H5
<B>Immunoblotting</B><BR/>Monoclonal Anti-PDE5A, <B>Cat. No. WH0008654M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~38.21 kDa using immunogen protein lysate.

Monoclonal Anti-PDE5A antibody produced in mouse - SAB1404610 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F11
<B>Immunoblotting</B><BR/>Monoclonal Anti-PDE5A: <B>Cat. No. SAB1404610</B>: Antibody concentration: 1 μg/mL. Specific band of ~38.2 kDa using immunogen protein lysate.

PDE5A antibody - C-terminal region (ARP63250_P050) - ARP63250_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PDE5A-Antibody - AF1804a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF1804a staining (0.3 µg/ml) of human lung lysate (RIPA buffer, 30 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Search more