| Gene Symbol |
PPP1R1A
|
| Entrez Gene |
5502
|
| Alt Symbol |
I1, IPP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 1, regulatory (inhibitor) subunit 1A
|
| Other Description |
I-1|IPP-1|inhibitor-1|protein phosphatase 1 regulatory subunit 1A|protein phosphatase inhibitor 1|protein phosphatase inhibitor-1
|
| Swissprots |
Q6IB01 Q13522 Q8WWV2 Q8TBJ2
|
| Accessions |
EAW96792 Q13522 AK123969 BAC85737 AY063766 AAL48321 BC022470 AAH22470 BM876308 BP211831 CR457003 CAG33284 U48707 AAB02402 XM_005268995 XP_005269052 XM_006719471 XP_006719534 XM_011538521 XP_011536823 XM_011538522 XP_011536824 NM_006741 NP_006732
|
| Function |
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
|
| Top Pathways |
Long-term potentiation, Adrenergic signaling in cardiomyocytes
|